ArticleJournal of biological rhythms2012
Cellular requirements for LARK in the Drosophila circadian system.
Article in Journal of biological rhythms, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
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- Conserved sleep disturbances in FOXP1 syndrome originate from developmental dysregulation of peptidergic signaling.The Journal of clinical investigation · 2026Article
- Bmlark is essential for embryonic development.BMC genomics · 2024Article
- Roles for theJournal of biological rhythms · 2023Article
- The circadian clock gatesProceedings of the National Academy of Sciences of the United States of America · 2021Article
- The impact of the gut microbiome on memory and sleep inThe Journal of experimental biology · 2021Article
- Article
- Characterisation of protein isoforms encoded by the Drosophila Glycogen Synthase Kinase 3 gene shaggy.PloS one · 2020Article
- Calcium and cAMP directly modulate the speed of the Drosophila circadian clock.PLoS genetics · 2018Article
- Central and peripheral clocks are coupled by a neuropeptide pathway in Drosophila.Nature communications · 2017Article
- The molecular ticks of the Drosophila circadian clock.Current opinion in insect science · 2015Article
- Caste-specific RNA editomes in the leaf-cutting ant Acromyrmex echinatior.Nature communications · 2014Article
- Translational regulation of the DOUBLETIME/CKIδ/ε kinase by LARK contributes to circadian period modulation.PLoS genetics · 2014Article
- Brain proteomics of Anopheles gambiae.Omics : a journal of integrative biology · 2014Article
- Emerging roles for post-transcriptional regulation in circadian clocks.Nature neuroscience · 2013Review
- Adaptation of molecular circadian clockwork to environmental changes: a role for alternative splicing and miRNAs.Proceedings. Biological sciences · 2013Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
RNA-binding proteins mediate posttranscriptional functions in the circadian systems of multiple species. A conserved RNA recognition motif (RRM) protein encoded by the lark gene is postulated to serve circadian output and molecular oscillator functions in Drosophila and mammals, respectively. In no species, however, has LARK been eliminated, in vivo, to determine the consequences for circadian timing. The present study utilized RNA interference (RNAi) techniques in Drosophila to decrease LARK levels in clock neurons and other cell types in order to evaluate the circadian functions of the protein. Knockdown of LARK in timeless (TIM)- or pigment dispersing factor (PDF)-containing clock cells caused a significant number of flies to exhibit arrhythmic locomotor activity, demonstrating a requirement for the protein in pacemaker cells. There was no obvious effect on PER protein cycling in lark interference (RNAi) flies, but a knockdown within the PDF neurons was associated with increased PDF immunoreactivity at the dorsal termini of the small ventral lateral neuronal (s-LNv) projections, suggesting an effect on neuropeptide release. The expression of lark RNAi in multiple neurosecretory cell populations demonstrated that LARK is required within pacemaker and nonpacemaker cells for the manifestation of normal locomotor activity rhythms. Interestingly, decreased LARK function in the prothoracic gland (PG), a peripheral organ containing a clock required for the circadian control of eclosion, was associated with weak population eclosion rhythms or arrhythmicity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.