ReviewPflugers Archiv : European journal of physiology2012
Mitochondrial function and malfunction in the pathophysiology of pancreatitis.
Review in Pflugers Archiv : European journal of physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 29 citations in OpenAlex.
- Effect of Vitamin C on the Prognosis of Patients with Acute Pancreatitis-Related Acute Kidney Injury Admitted to the Intensive Care Unit: A Retrospective Study.Digestive diseases and sciences · 2026Article
- Role of Bifidobacterium animalis subsp. lactis BB-12 in mice with acute pancreatitis.AMB Express · 2025Article
- Association between the triglyceride-glucose index and the risk of acute kidney injury in critically ill patients with acute pancreatitis: a retrospective study.Journal of intensive care · 2025Article
- Isorhamnetin Alleviates Mitochondrial Injury in Severe Acute Pancreatitis via Modulation of KDM5B/HtrA2 Signaling Pathway.International journal of molecular sciences · 2024Article
- Pancreatitis in multiple acyl CoA dehydrogenase deficiency: An underdiagnosed complication.JIMD reports · 2021Article
- Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand.Cell metabolism · 2018Article
- Calcium and adenosine triphosphate control of cellular pathology: asparaginase-induced pancreatitis elicited via protease-activated receptor 2.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Article
- Reduced Pancreatic Exocrine Function and Organellar Disarray in a Canine Model of Acute Pancreatitis.PloS one · 2016Article
- Complex role for the immune system in initiation and progression of pancreatic cancer.World journal of gastroenterology · 2014Review
- Discovering the route from inflammation to pancreatic cancer.Minerva gastroenterologica e dietologica · 2012Review
- Specific mitochondrial functions in separate sub-cellular domains of pancreatic acinar cells.Pflugers Archiv : European journal of physiology · 2012Review
- A Special Issue on the cell-specific roles of mitochondrial Ca²⁺ handling.Pflugers Archiv : European journal of physiology · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
As a primary energy producer, mitochondria play a fundamental role in pancreatic exocrine physiology and pathology. The most frequent aetiology of acute pancreatitis is either gallstones or heavy alcohol consumption. Repeated episodes of acute pancreatitis can result in the development of chronic pancreatitis and increase the lifetime risk of pancreatic cancer 100-fold. Pancreatic cancer is one of the most common causes of cancer mortality with only about 3-4 % of patients surviving beyond 5 years. It has been shown that acute pancreatitis involves Ca²⁺ overload and overproduction of reactive oxygen species in pancreatic acinar cells. Both factors significantly affect mitochondria and lead to cell death. The pathogenesis of inflammation in acute and chronic pancreatitis is tightly linked to the induction of necrosis and apoptosis. There is currently no specific therapy for pancreatitis, but recent findings of an endogenous protective mechanism against Ca²⁺ overload--and particularly the potential to boost this protection--bring hope of new therapeutic approaches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.