ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2013
Laxative prescriptions to cancer outpatients receiving opioids: a study from the Norwegian prescription database.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 24 citations in OpenAlex.
- Inadequate management of opioid-induced constipation in European cancer pain patients: results of a real-world, multicentre, observational study ("E-StOIC").Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Observational
- Prescribing practices, patterns, and potential harms in patients receiving palliative care: A systematic scoping review.Exploratory research in clinical and social pharmacy · 2021Article
- Delphi consensus on strategies in the management of opioid-induced constipation in cancer patients.BMC palliative care · 2021Article
- Optimal treatment of opioid induced constipation in daily clinical practice - an observational study.BMC palliative care · 2019Observational
- Pathophysiology and management of opioid-induced constipation: European expert consensus statement.United European gastroenterology journal · 2019Review
- Opioids in Gastroenterology: Treating Adverse Effects and Creating Therapeutic Benefits.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2017Review
- Emerging treatments in neurogastroenterology: a multidisciplinary working group consensus statement on opioid-induced constipation.Neurogastroenterology and motility · 2014Review
- Managing cancer pain at the end of life with multiple strong opioids: a population-based retrospective cohort study in primary care.PloS one · 2014Article
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Authors and funding
5 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundDuring opioid treatment of cancer pain, constipation is one of the most prevalent and bothersome side effects. Guidelines suggest that treatment with laxatives should be initiated when opioid therapy is started.
aimThis study aims: (1) to determine to what extent patients, starting on opioids due to cancer pain, receive laxatives; (2) to examine the temporal relationship between initiation of opioid therapy and initiation of treatment with laxatives; and (3) to study to which extent the treatment follows current guidelines.
methodsData from the Norwegian prescription database (NorPD) were used to investigate dispensed prescriptions of laxatives to outpatients in Norway, who are receiving opioids for cancer pain. Data from NorPD cover all dispensed prescriptions of drugs to outpatients, making it possible to follow patients over time. The study cohort was followed from 2005 to the end of 2008.
resultsOf 2,982 patients who started opioid therapy directly with WHO step III opioids, 1,325 patients (44.4 %) did not receive laxatives during the study period. Only 738 patients (24.7 %) received laxatives at the same time as opioid therapy was initiated. Another 657 patients (22.0 %) received laxatives after their initiation of opioids at some time during the study period.
conclusionOf those who started directly on a strong opioid, only one fourth received laxatives concomitantly with the first opioid, and nearly half did not receive laxatives at all. These findings indicate that the current guidelines are not followed.
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