ArticleAge (Dordrecht, Netherlands)2013
Effects of aging and sex on voluntary activation and peak relaxation rate of human elbow flexors studied with motor cortical stimulation.
Article in Age (Dordrecht, Netherlands), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Sex Differences in Adaptations in Muscle Strength and Size Following Resistance Training in Older Adults: A Systematic Review and Meta-analysis.Sports medicine (Auckland, N.Z.) · 2021Pooled it
- Age-related Deficits in Voluntary Activation: A Systematic Review and Meta-analysis.Medicine and science in sports and exercise · 2020Pooled it
- The influence of motor cortical stimulus intensity on the relaxation rate of human lower limb muscles.Experimental brain research · 2013Trial
- Sarco/endoplasmatic reticulum calcium ATPase activity in healthy muscle and Brody disease.Biochemistry and biophysics reports · 2026Article
- The interactive effects of biological sex and skeletal muscle fiber properties on knee-extensor muscle relaxation induced by TMS in unfatigued and fatigued states.European journal of applied physiology · 2026Article
- From twitch to relaxation: Obesity dysregulates muscle contractile function.Physiological reports · 2026Article
- Sex differences in the rate of torque development and torque-velocity relationship are due to maximal strength only.European journal of applied physiology · 2025Article
- Delayed neuromuscular fatigue recovery unveils reduced fatigue tolerance in elderly following maximal intermittent exercise.European journal of applied physiology · 2024Article
- Field-Based Estimates of Muscle Quality Index Determine Timed-Up-and-Go Test Performance in Obese Older Women.Clinical interventions in aging · 2023Article
- Advancements in the Protocol for Rate of Force Development/Relaxation Scaling Factor Evaluation.Frontiers in human neuroscience · 2021Article
- Use of transcranial magnetic stimulation to assess relaxation rates in unfatigued and fatigued knee-extensor muscles.Experimental brain research · 2021Article
- Central and Peripheral Neuromuscular Adaptations to Ageing.Journal of clinical medicine · 2020Review
- KBTBD13 is an actin-binding protein that modulates muscle kinetics.The Journal of clinical investigation · 2020Article
- A novel method to assess rate of force relaxation: reliability and comparisons with rate of force development across various muscles.European journal of applied physiology · 2019Article
- Determining the potential sites of neural adaptation to cross-education: implications for the cross-education of muscle strength.European journal of applied physiology · 2018Review
- Performance Fatigability: Mechanisms and Task Specificity.Cold Spring Harbor perspectives in medicine · 2018Review
- Skeletal muscle performance and ageing.Journal of cachexia, sarcopenia and muscle · 2018Review
- Voluntary activation and variability during maximal dynamic contractions with aging.European journal of applied physiology · 2017Article
- The effect of muscle length on transcranial magnetic stimulation-induced relaxation rate in the plantar flexors.Physiological reports · 2017Article
- The aging neuromuscular system and motor performance.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Data are equivocal on whether voluntary activation is preserved or decreased in old compared to young adults. Further, data are scant on the effect of age on the rate of muscle relaxation when the muscle is contracting voluntarily. Assessment of both measures with transcranial magnetic stimulation (TMS) yields information which cannot be obtained with traditional peripheral nerve stimulation. Hence, voluntary activation and peak relaxation rate of the elbow flexors were assessed with TMS during repeated maximal efforts in 30 men and 28 women between the ages of 22-84 years. Voluntary activation was similar for the two sexes (P = 0.154) and was not affected by age in men (96.2 ± 2.7 %; P = 0.887) or women (95.1 ± 3.0 %; P = 0.546). Men had a significantly faster peak rate of relaxation than women in absolute units (-880.0 ± 223.2 vs. -360.2 ± 78.5 Nm/ s, respectively; P < 0.001) and when normalized to subject strength (-12.5 ± 2.1 vs. -8.7 ± 1.0 s(-1), respectively; P < 0.001). Absolute and normalized relaxation rates slowed with age in men (P = 0.002 and P = 0.006, respectively), but not women (P = 0.142 and P = 0.950, respectively). Across the age range studied, all subjects, regardless of age or sex, were able to achieve high voluntary activation scores for the elbow flexors (~95 %). In contrast, peak relaxation rate was markedly faster in men than women and slowed with age in men but not women. Normalization of relaxation rates to strength did not affect the influence of age or sex.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.