ReviewJournal of endocrinological investigation2012
Advances in the epidemiology, pathogenesis, and management of Cushing's syndrome complications.
Review in Journal of endocrinological investigation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.
- Combined therapy of diabetic peripheral neuropathy with breviscapine and mecobalamin: a systematic review and a meta-analysis of Chinese studies.BioMed research international · 2015Pooled it
- Salivary cortisol is a useful tool to assess the early response to pasireotide in patients with Cushing's disease.Pituitary · 2015Trial
- Possible efficacy of Lavender and Tea tree oils in the treatment of young women affected by mild idiopathic hirsutism.Journal of endocrinological investigation · 2013Trial
- Hypercortisolism: Causes, Consequences and Clinical Significance - A Review of Pathophysiology.Diabetes, obesity & metabolism · 2026Review
- Clinical Practice Patterns in Bone Health Assessment and Management in Endogenous Cushing's Syndrome.Clinical endocrinology · 2026Article
- Unravelling the role of natural herbs for the management of diabetes mellitus.Diabetology & metabolic syndrome · 2025Review
- Molecular puzzle of insulin: structural assembly pathways and their role in diabetes.Frontiers in cell and developmental biology · 2025Review
- Review
- Is cortisol an endogenous mediator of erectile dysfunction in the adult male?Translational andrology and urology · 2023Article
- The Significance of Dual-Energy X-ray Absorptiometry (DXA) Examination in Cushing's Syndrome-A Systematic Review.Diagnostics (Basel, Switzerland) · 2023Review
- Pasireotide treatment in Cushing's disease: A single tertiary center's experience.Turkish journal of medical sciences · 2022Article
- Perioperative Management of a Patient With Cushing Disease.Journal of the Endocrine Society · 2022Article
- Mesenchymal Stem Cells Exposed to Persistently High Glucocorticoid Levels Develop Insulin-Resistance and Altered Lipolysis: A PromisingFrontiers in endocrinology · 2022Article
- Assessment of non-traumatic vertebral fractures in Cushing's syndrome patients.Journal of endocrinological investigation · 2021Article
- Hypothalamic-Pituitary Diseases and Erectile Dysfunction.Journal of clinical medicine · 2021Review
- Lipid Abnormalities in Patients With Cushing's Disease and Its Relationship With Impaired Glucose Metabolism.Frontiers in endocrinology · 2020Article
- Cushing Syndrome: The Role of MSCs in Wound Healing, Immunosuppression, Comorbidities, and Antioxidant Imbalance.Frontiers in cell and developmental biology · 2019Article
- Demographic Characteristics, Etiology, and Comorbidities of Patients with Cushing's Syndrome: A 10-Year Retrospective Study at a Large General Hospital in China.International journal of endocrinology · 2019Article
- Clinical Investigation of Adrenal Incidentalomas in Japanese Patients of the Fukuoka Region with Updated Diagnostic Criteria for Sub-clinical Cushing's Syndrome.Internal medicine (Tokyo, Japan) · 2018Article
- Sexual function in women with Cushing's Syndrome: A controlled study.Turkish journal of urology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cushing's syndrome (CS) is a clinical condition resulting from chronic exposure to glucocorticoid excess. As a consequence, hypercortisolism contributes significantly to the early development of systemic disorders by direct and/or indirect effects. Complications such as obesity, hypertension, diabetes, dyslipidemia, and hypercoagulability cause premature atherosclerosis and increase cardiovascular mortality. Impairment of the skeletal system is a relevant cause of morbidity and disability in these patients especially due to the high prevalence of vertebral fractures. In addition, muscle weakness, emotional lability, depression, and impairment of quality of life are very common. Clinical management of these patients is complex and should be particularly careful in identifying global cardiovascular risks and aim at controlling all complications. Although the primary goal in the prevention and treatment of complications is the correction of hypercortisolism, treatment does not completely eliminate these comorbidities. Given that cardiovascular risk and fracture risk can persist after cure, early detection of each morbidity could prevent the development of irreversible damage. In this review we present the various complications of CS and their pathogenetic mechanisms. We also suggest the clinical management of these patients based on our extensive clinical experience and on the available literature.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.