ArticleImmunogenetics2012
Organization of Mhc class II A and B genes in the tilapiine fish Oreochromis.
Article in Immunogenetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 26 citations in OpenAlex.
- Intra-specific copy number variation of MHC class II genes in the Siamese fighting fish.Immunogenetics · 2022Article
- Fate of MHCII in salmonids following 4WGD.Immunogenetics · 2021Article
- Analysis of structural variants in four African cichlids highlights an association with developmental and immune related genes.BMC evolutionary biology · 2020Article
- Major Histocompatibility Complex in Osteichthyes.Journal of veterinary research · 2020Article
- Evolution of Copy Number at the MHC Varies across the Avian Tree of Life.Genome biology and evolution · 2019Article
- An exploration of the links between parasites, trophic ecology, morphology, and immunogenetics in the Lake Tanganyika cichlid radiation.Hydrobiologia · 2019Article
- Molecular characterization of MHC class IIB genes of sympatric Neotropical cichlids.BMC genetics · 2017Article
- MHC and Evolution in Teleosts.Biology · 2016Review
- Locus number estimation of MHC class II B in stone flounder and Japanese flounder.International journal of molecular sciences · 2015Article
- A comprehensive analysis of teleost MHC class I sequences.BMC evolutionary biology · 2015Article
- Gene duplication in an African cichlid adaptive radiation.BMC genomics · 2014Article
- Comprehensive analysis of medaka major histocompatibility complex (MHC) class II genes: implications for evolution in teleosts.Immunogenetics · 2013Article
- Comprehensive analysis of MHC class II genes in teleost fish genomes reveals dispensability of the peptide-loading DM system in a large part of vertebrates.BMC evolutionary biology · 2013Article
- Differential modes of MHC class IIB gene evolution in cichlid fishes.Immunogenetics · 2013Article
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Perch-like fishes of the family Cichlidae are models for the study of speciation. An important tool in these studies is the major histocompatibility complex (Mhc) and its organization. The present study takes the first step toward the elucidation of the Mhc class II gene organization in the tilapiine fish Oreochromis niloticus (Orni). Using class II A- and class II B-specific probes, Mhc-bearing clones were identified and isolated from a bacterial artificial chromosome (BAC) library. The analysis of these clones by a combination of molecular, genetic-mapping, and phylogenetic methods led to the identification of nine class II A and 15 class II B loci. Genes at these loci constitute two families, which we designate as class IIa and class IIb families. Each of the families contains A and B loci. Some genes in both families are expressed and functional. The two families differ in their chromosomal location (they are unlinked) and their mode of evolution. The class IIa family genes are conserved across different teleost taxonomical orders, whereas the class IIb family genes are apparently products of multiple, more recent, rounds of gene duplications. The rounds established at least five monophyletic groups of genes. The founding unit of each monophyletic group might have been a pair of class II A and B loci.
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