ArticleMethods (San Diego, Calif.)2012
Computational detection and analysis of sequences with duplex-derived interstrand G-quadruplex forming potential.
Article in Methods (San Diego, Calif.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Chromatin Hubs: A biological and computational outlook.Computational and structural biotechnology journal · 2022Review
- Fundamentals of G-quadruplex biology.Annual reports in medicinal chemistry · 2020Article
- Identification of G-quadruplex clusters by high-throughput sequencing of whole-genome amplified products with a G-quadruplex ligand.Scientific reports · 2018Article
- Re-evaluation of G-quadruplex propensity with G4Hunter.Nucleic acids research · 2016Article
- Guanine quadruplex structures localize to heterochromatin.Nucleic acids research · 2016Article
- G-Quadruplexes Involving Both Strands of Genomic DNA Are Highly Abundant and Colocalize with Functional Sites in the Human Genome.PloS one · 2016Article
- Duplex stem-loop-containing quadruplex motifs in the human genome: a combined genomic and structural study.Nucleic acids research · 2015Article
- Flexibility and structural conservation in a c-KIT G-quadruplex.Nucleic acids research · 2015Article
- Association of G-quadruplex forming sequences with human mtDNA deletion breakpoints.BMC genomics · 2014Article
- Using hidden Markov models to investigate G-quadruplex motifs in genomic sequences.BMC genomics · 2014Article
- Nucleic acid detection using G-quadruplex amplification methodologies.Methods (San Diego, Calif.) · 2013Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Bioinformatic approaches to the identification of genomic sequences having G-quadruplex forming potential (QFP) has enabled important tests of the structure of these sequences in vitro and of their behavior under conditions where the formation or function of G-quadruplexes is modulated in vivo. Several similar approaches to identifying intramolecular QFP (i.e. forming among G-runs on one strand of DNA) have been developed previously, but none appears to perfectly predict G-quadruplex formation. Here we describe a new approach, which complements and differs from prior approaches in that it identifies motifs containing G-runs on both strands of duplex DNA that could contribute to G-quadruplex structures. We call these motifs duplex-derived interstrand QFP (ddiQFP), and illustrate their potential applications by describing their genomic distribution and an example of their correspondence to loci targeted by a G-quadruplex-unwinding DNA helicase in yeast.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.