Evidence map›Paper›PMID 22652137›Full record

ArticleNeurologia (Barcelona, Spain)2013

Assessing the diagnostic accuracy (DA) of the Spanish version of the informant-based AD8 questionnaire.

C Carnero Pardo, R de la Vega Cotarelo, S López Alcalde, C Martos Aparicio, R Vílchez Carrillo, E Mora Gavilán, J E Galvin

Abstract readEvaluation Study
In one paragraph

Article in Neurologia (Barcelona, Spain), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. AD-8 for detection of dementia across a variety of healthcare settings.The Cochrane database of systematic reviews · 2019
    Pooled it
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Development and validation of the Ascertain Dementia 8 (AD8) Thai version.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2022
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Reliability and Feasibility of the Memory Associative Test TMA-93.Journal of Alzheimer's disease reports · 2020
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

C Carnero PardoServicio de Neurología, Hospital Universitario Virgen de las Nieves, Granada, España. ccarnero@neurocenter.es
R de la Vega Cotarelo
S López Alcalde
C Martos Aparicio
R Vílchez Carrillo
E Mora Gavilán
J E Galvin

Funding

PSYCHOSOCIAL COREP30AG008051 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MITTELMAN, MARY SHERMAN · 1990 to 2019
$36.1M
Multicultural Community Dementia Screening.R01AG040211 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GALVIN, JAMES E · 2011 to 2018
$3.2M
NIA NIH HHS P30 AG008051NIA NIH HHS R01 AG040211
6 · The paper itself

Abstract

introductionThe AD8 is a brief informant-based questionnaire that may also be self-administered, and which aids in identifying cognitive impairment (CI). Our goal is to assess the diagnostic accuracy (DA) of a Spanish version of that questionnaire. MATERIAL AND

methodsCross-sectional study of a clinical sample of patient/informant dyads including 330 subjects with suspected CI or dementia (DEM) and 71 controls. We evaluated internal consistency (Cronbach's alpha) and validity (partial correlations with GDS stage, Fototest results and functional index measure [FIM]). We assessed DA for CI vs no CI (GDS stage 3-4) using the area under the ROC curve (AUC), and the cut-off with the highest Youden index was determined to be optimal.

resultsIn the sample, 105 subjects had no CI, 99 had CI without DEM and 203 had DEM. Internal consistency was high (α 0.90, 95% confidence interval: 0.89-0.92), as were correlations with the GDS score (r=0.72, P<.001), Fototest results (r=-0.61, P<.001) and FIM (r=0.59, P<.001). The AUC for AD8 was 0.90 (95% confidence interval: 0.86-0.93), which was not significantly different from that of the Fototest (AUC 0.93, 95% confidence interval: 0.89-0.96). The optimal cut-off point was 3/4 with a sensitivity of 0.93 (95% confidence interval: 0.88-0.96) and a specificity of 0.81 (95% confidence interval: 0.72-0.88); 88.8% of the classifications were correct. Combined use of AD8 and the Fototest significantly improved the DA of both (AUC 0.96, 95% confidence interval: 0.93-0.98, P<.05).

conclusionsThe Spanish version of the AD8 questionnaire preserves the psychometric qualities and DA of the original. Using this test in combination with the Fototest significantly increases the DA of both tests.

Indexed as

Surveys and QuestionnairesAgedAged, 80 and overCognition DisordersCross-Sectional StudiesData Interpretation, StatisticalFemaleHumansLanguageMaleMiddle AgedNeuropsychological TestsProspective StudiesReproducibility of ResultsROC Curve

Identifiers

PMID22652137
PMCPMC3485452

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.