ArticleAmerican journal of respiratory and critical care medicine2012
Vitamin D insufficiency and severe asthma exacerbations in Puerto Rican children.
Article in American journal of respiratory and critical care medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02301520 (Vitamin D Deficiency, Iodine Deficiency and Lead Levels in Haitian Infants and Children.), which is not on this map. Cited by 98 papers, 9 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Vitamin D Deficiency, Iodine Deficiency and Lead Levels in Haitian Infants and Children.
Who cites it
98 citing papers in PubMed, 9 syntheses or guidelines pooled it, 224 citations in OpenAlex.
- The Role of Vitamin D in Severity and Control of Asthma in Children and Adolescents: A Systematic Review and Meta-Analysis.Pediatric pulmonology · 2026Pooled it
- Associations between vitamin D status and biomarkers linked with inflammation in patients with asthma: a systematic review and meta-analysis of interventional and observational studies.Respiratory research · 2024Pooled it
- Vitamin D for the management of asthma.The Cochrane database of systematic reviews · 2023Pooled it
- A Meta-Analysis on Vitamin D Supplementation and Asthma Treatment.Frontiers in nutrition · 2022Pooled it
- Meta-analysis of vitamin D and lung function in patients with asthma.Respiratory research · 2019Pooled it
- Pooled it
- Vitamin D supplementation to prevent asthma exacerbations: a systematic review and meta-analysis of individual participant data.The Lancet. Respiratory medicine · 2017Pooled it
- Vitamin D Supplementation for Childhood Asthma: A Systematic Review and Meta-Analysis.PloS one · 2015Pooled it
- Preterm birth and childhood wheezing disorders: a systematic review and meta-analysis.PLoS medicine · 2014Pooled it
- Effect of vitamin D supplementation on total and allergen-specific IgE in children with asthma and low vitamin D levels.The Journal of allergy and clinical immunology · 2022Trial
- Trial
- Income is an independent risk factor for worse asthma outcomes.The Journal of allergy and clinical immunology · 2018Trial
- 25-hydroxy vitamin D levels are associated with childhood asthma in a population-based study in Peru.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2015Trial
- The association between vitamin D status and the rate of exacerbations requiring oral corticosteroids in preschool children with recurrent wheezing.The Journal of allergy and clinical immunology · 2014Trial
- Micronutrients in Pediatric Asthma: Biological Mechanisms and Clinical Evidence-A Narrative Review.Nutrients · 2026Review
- Nutrition as a Modifiable Factor in Optimizing Respiratory Health: Evidence from Pulmonary Function Tests.Children (Basel, Switzerland) · 2026Review
- Nonlinear relationship between vitamin D status on admission and bronchopulmonary dysplasia in preterm infants.Pediatric research · 2025Article
- Serum inflammatory factors, vitamin D levels, and asthma severity in children with comorbid asthma and obesity/overweight: a comparative study.Frontiers in pediatrics · 2025Article
- Persistent cat ownership and asthma in a longitudinal study of Puerto Rican youth.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2024Article
- Unveiling the potent effect of vitamin D: harnessing Nrf2/HO-1 signaling pathways as molecular targets to alleviate urban particulate matter-induced asthma inflammation.BMC pulmonary medicine · 2024Article
38 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 7 institutions in 2 countries.
Funding
Abstract
rationaleVitamin D insufficiency (a serum 25(OH)D <30 ng/ml) has been associated with severe asthma exacerbations, but this could be explained by underlying racial ancestry or disease severity. Little is known about vitamin D and asthma in Puerto Ricans.
objectivesTo examine whether vitamin D insufficiency is associated with severe asthma exacerbations in Puerto Rican children, independently of racial ancestry, atopy, and time outdoors.
methodsA cross-sectional study was conducted of 560 children ages 6-14 years with (n = 287) and without (n = 273) asthma in San Juan, Puerto Rico. We measured plasma vitamin D and estimated the percentage of African racial ancestry among participants using genome-wide genotypic data. We tested whether vitamin D insufficiency is associated with severe asthma exacerbations, lung function, or atopy (greater than or equal to one positive IgE to allergens) using logistic or linear regression. Multivariate models were adjusted for African ancestry, time outdoors, atopy, and other covariates. MEASUREMENTS AND MAIN
resultsVitamin D insufficiency was common in children with (44%) and without (47%) asthma. In multivariate analyses, vitamin D insufficiency was associated with higher odds of greater than or equal to one severe asthma exacerbation in the prior year (odds ratio [OR], 2.6; 95% confidence interval [CI], 1.5-4.9; P = 0.001) and atopy, and a lower FEV(1)/FVC in cases. After stratification by atopy, the magnitude of the association between vitamin D insufficiency and severe exacerbations was greater in nonatopic (OR, 6.2; 95% CI, 2-21.6; P = 0.002) than in atopic (OR, 2; 95% CI, 1-4.1; P = 0.04) cases.
conclusionsVitamin D insufficiency is associated with severe asthma exacerbations in Puerto Rican children, independently of racial ancestry, atopy, or markers of disease severity or control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.