ArticleJournal of the American Chemical Society2012
Microfluidic electrochemical sensor for on-line monitoring of aerosol oxidative activity.
Article in Journal of the American Chemical Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 100 citations in OpenAlex.
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- ZnO Nanowire-Anchored Microfluidic Device With Herringbone Structure Fabricated by Maskless Photolithography.Biomedical engineering and computational biology · 2020Article
- Polycaprolactone-enabled sealing and carbon composite electrode integration into electrochemical microfluidics.Lab on a chip · 2019Article
- Electrochemical Dithiothreitol Assay for Large-Scale Particulate Matter Studies.Aerosol science and technology : the journal of the American Association for Aerosol Research · 2019Article
- Physiochemical characteristics and oxidative potential of ambient air particulate matter (PMJournal of environmental health science & engineering · 2018Article
- A Universal Biomolecular Concentrator To Enhance Biomolecular Surface Binding Based on Acoustic NEMS Resonator.ACS central science · 2018Article
- An online monitor of the oxidative capacity of aerosols (o-MOCA).Atmospheric measurement techniques · 2017Article
- A bias in the "mass-normalized" DTT response - an effect of non-linear concentration-response curves for copper and manganese.Atmospheric environment (Oxford, England : 1994) · 2016Article
- Paper-based analytical devices for environmental analysis.The Analyst · 2016Review
- New Methods for Personal Exposure Monitoring for Airborne Particles.Current environmental health reports · 2015Review
- A new method and tool for detection and quantification of PM oxidative potential.Environmental science and pollution research international · 2015Article
- A Simple Microfluidic Electrochemical HPLC Detector for Quantifying Fenton Reactivity from Welding Fumes.Analytical methods : advancing methods and applications · 2014Article
- Integrated immunoisolation and protein analysis of circulating exosomes using microfluidic technology.Lab on a chip · 2014Article
- LABORATORY EVALUATION OF A MICROFLUIDIC ELECTROCHEMICAL SENSOR FOR AEROSOL OXIDATIVE LOAD.Aerosol science and technology : the journal of the American Association for Aerosol Research · 2014Article
- Determination of aerosol oxidative activity using silver nanoparticle aggregation on paper-based analytical devices.The Analyst · 2013Article
- In vivo monitoring of serotonin in the striatum of freely moving rats with one minute temporal resolution by online microdialysis-capillary high-performance liquid chromatography at elevated temperature and pressure.Analytical chemistry · 2013Article
- Microfluidic paper-based analytical device for aerosol oxidative activity.Environmental science & technology · 2013Article
- Micro total analysis systems: fundamental advances and applications in the laboratory, clinic, and field.Analytical chemistry · 2013Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Particulate matter (PM) air pollution has a significant impact on human morbidity and mortality; however, the mechanisms of PM-induced toxicity are poorly defined. A leading hypothesis states that airborne PM induces harm by generating reactive oxygen species in and around human tissues, leading to oxidative stress. We report here a system employing a microfluidic electrochemical sensor coupled directly to a particle-into-liquid sampler (PILS) system to measure aerosol oxidative activity in an on-line format. The oxidative activity measurement is based on the dithiothreitol (DTT) assay, where, after being oxidized by PM, the remaining reduced DTT is analyzed by the microfluidic sensor. The sensor consists of an array of working, reference, and auxiliary electrodes fabricated in a poly(dimethylsiloxane)-based microfluidic device. Cobalt(II) phthalocyanine-modified carbon paste was used as the working electrode material, allowing selective detection of reduced DTT. The electrochemical sensor was validated off-line against the traditional DTT assay using filter samples taken from urban environments and biomass burning events. After off-line characterization, the sensor was coupled to a PILS to enable on-line sampling/analysis of aerosol oxidative activity. Urban dust and industrial incinerator ash samples were aerosolized in an aerosol chamber and analyzed for their oxidative activity. The on-line sensor reported DTT consumption rates (oxidative activity) in good correlation with aerosol concentration (R(2) from 0.86 to 0.97) with a time resolution of approximately 3 min.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.