ArticleMolecular microbiology2012
Role of DNA base excision repair in the mutability and virulence of Streptococcus mutans.
Article in Molecular microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Genomic adaptation in group BmBio · 2026Article
- Genomic adaptation in group BbioRxiv : the preprint server for biology · 2025Article
- The Effect of Bovine Trypsin on the Adhesion and pH of Dental Plaque Biofilms: An In Vitro Study.International dental journal · 2024Article
- Transcriptome Analysis ofGenes · 2023Article
- Mechanistic insights into the inhibitory effect of theaflavins on virulence factors production in Streptococcus mutans.AMB Express · 2021Article
- Vitamin D Compounds Are Bactericidal against Streptococcus mutans and Target the Bacitracin-Associated Efflux System.Antimicrobial agents and chemotherapy · 2018Article
- Transcriptome responses of Streptococcus mutans to peroxide stress: identification of novel antioxidant pathways regulated by Spx.Scientific reports · 2017Article
- Acid-adaptive mechanisms of Streptococcus mutans-the more we know, the more we don't.Molecular oral microbiology · 2017Review
- Transcriptional profile of glucose-shocked and acid-adapted strains of Streptococcus mutans.Molecular oral microbiology · 2015Article
- The formation of Streptococcus mutans persisters induced by the quorum-sensing peptide pheromone is affected by the LexA regulator.Journal of bacteriology · 2015Article
- Article
- β-Phosphoglucomutase contributes to aciduricity in Streptococcus mutans.Microbiology (Reading, England) · 2014Article
- Streptococcus mutans: a new Gram-positive paradigm?Microbiology (Reading, England) · 2013Review
- Evolution in fast forward: a potential role for mutators in accelerating Staphylococcus aureus pathoadaptation.Journal of bacteriology · 2013Article
- MUTYH DNA glycosylase: the rationale for removing undamaged bases from the DNA.Frontiers in genetics · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The oral pathogen, Streptococcus mutans, possesses inducible DNA repair defences for protection against pH fluctuations and production of reactive oxygen metabolites such as hydrogen peroxide (H(2) O(2) ), which are present in the oral cavity. DNA base excision repair (BER) has a critical role in genome maintenance by preventing the accumulation of mutations associated with environmental factors and normal products of cellular metabolism. In this study, we examined the consequences of compromising the DNA glycosylases (Fpg and MutY) and endonucleases (Smx and Smn) of the BER pathway and their relative role in adaptation and virulence. Enzymatic characterization of the BER system showed that it protects the organism against the effects of the highly mutagenic lesion, 7,8-dihydro-8-oxo-2'-deoxyguanine (8-oxo-dG). S. mutans strains lacking a functional Fpg, MutY or Smn showed elevated spontaneous mutation frequencies; and, these mutator phenotypes correlated with the ability of the strains to survive killing by acid and oxidative agents. In addition, in the Galleria mellonella virulence model, strains of S. mutans deficient in Fpg, MutY and Smn showed increased virulence as compared with the parent strain. Our results suggest that, for S. mutans, mutator phenotypes, due to loss of BER enzymes, may confer an advantage to virulence of the organism.
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