ArticleBMC biology2012
Phylogenomics supports microsporidia as the earliest diverging clade of sequenced fungi.
Article in BMC biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers.
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Who cites it
89 citing papers in PubMed.
- Revealing the Modulatory Role of Microsporidian circRNAs in the Infection of Honey Bee Workers.Insects · 2026Article
- Molecular clock dating using complex mixture models: applied to ancient symbionts.Molecular biology and evolution · 2026Article
- Microsporidian Encephalitozoon hellem inhibits host mitophagy by inducing ERAD to degrade BNIP3L.PLoS pathogens · 2026Article
- Sexually transmitted enteric infections in men who have sex with men.Clinical microbiology reviews · 2025Review
- Article
- Diversity of Rhizophydiales (Chytridiomycota) in Thailand: unveiling the hidden gems of the Kingdom.IMA fungus · 2024Article
- In Vitro Cultivation forMicroorganisms · 2024Article
- Article
- MicroAnnot: A Dedicated Workflow for Accurate Microsporidian Genome Annotation.International journal of molecular sciences · 2024Article
- Nematocida displodere mechanosensitive ion channel of small conductance 2 assembles into a unique 6-channel super-structure in vitro.PloS one · 2024Article
- Functional characterization of Nosema bombycis (microsporidia) trehalase 3.Parasitology research · 2023Article
- Incongruence in the phylogenomics era.Nature reviews. Genetics · 2023Review
- Geographic population structure of the honeybee microsporidian parasite Vairimorpha (Nosema) ceranae in the South West Indian Ocean.Scientific reports · 2023Article
- Germination of Microsporidian Spores: The Known and Unknown.Journal of fungi (Basel, Switzerland) · 2023Review
- Genomic and phenotypic evolution of nematode-infecting microsporidia.PLoS pathogens · 2023Article
- Engineered gut symbiont inhibits microsporidian parasite and improves honey bee survival.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Prevalence ofAnimals : an open access journal from MDPI · 2023Article
- Telomere-to-Telomere genome assemblies of human-infecting Encephalitozoon species.BMC genomics · 2023Article
- Structural and Functional Annotation of Hypothetical Proteins from the Microsporidia SpeciesInternational journal of molecular sciences · 2023Article
- Article
29 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMicrosporidia is one of the taxa that have experienced the most dramatic taxonomic reclassifications. Once thought to be among the earliest diverging eukaryotes, the fungal nature of this group of intracellular pathogens is now widely accepted. However, the specific position of microsporidia within the fungal tree of life is still debated. Due to the presence of accelerated evolutionary rates, phylogenetic analyses involving microsporidia are prone to methodological artifacts, such as long-branch attraction, especially when taxon sampling is limited.
resultsHere we exploit the recent availability of six complete microsporidian genomes to re-assess the long-standing question of their phylogenetic position. We show that microsporidians have a similar low level of conservation of gene neighborhood with other groups of fungi when controlling for the confounding effects of recent segmental duplications. A combined analysis of thousands of gene trees supports a topology in which microsporidia is a sister group to all other sequenced fungi. Moreover, this topology received increased support when less informative trees were discarded. This position of microsporidia was also strongly supported based on the combined analysis of 53 concatenated genes, and was robust to filters controlling for rate heterogeneity, compositional bias, long branch attraction and heterotachy.
conclusionsAltogether, our data strongly support a scenario in which microsporidia is the earliest-diverging clade of sequenced fungi.
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