ArticleOrganic letters2012
Acetylphosphonate as a surrogate of acetate or acetamide in organocatalyzed enantioselective aldol reactions.
Article in Organic letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 56 citations in OpenAlex.
- Organocatalytic Asymmetric Aldol Reaction of Arylglyoxals and Hydroxyacetone: Enantioselective Synthesis of 2,3-Dihydroxy-1,4-diones.Molecules (Basel, Switzerland) · 2020Article
- Enantioselective synthesis of spiro[Synthetic communications · 2019Article
- Isatin derivatives in reactions with phosphorus(III-V) compounds.Chemistry of heterocyclic compounds · 2015Article
- Asymmetric Aldol Reaction of 3-Acetyl-2Advanced synthesis & catalysis · 2014Article
- Organocatalyzed asymmetric Michael reaction of β-aryl-α-ketophosphonates and nitroalkenes.Tetrahedron letters · 2013Article
- Highly enantioselective three-component direct Mannich reactions of unfunctionalized ketones catalyzed by bifunctional organocatalysts.Organic letters · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Highly enantioselective aldol reactions of acetylphosphonates and activated carbonyl compounds was realized with cinchona alkaloid derived catalysts, in which the acetylphosphonate was directly used as an enolate precursor for the first time. The aldol product obtained was converted in situ to its corresponding ester or amide through methanolysis or aminolysis. The overall process may be viewed as formal highly enantioselective acetate or acetamide aldol reactions, which are very difficult to achieve directly with organocatalytic methods.
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Registered trials
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