ArticleNeurogastroenterology and motility2012
Platelet-derived growth factor receptor α (PDGFRα)-expressing "fibroblast-like cells" in diabetic and idiopathic gastroparesis of humans.
Article in Neurogastroenterology and motility, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Colonic dysmotility regulated by downregulation of PDGFRα+ cells / SK3 channel in DSS-induced colitis mice.PloS one · 2024Article
- Reconsideration of the Gastroparetic Syndrome.Current gastroenterology reports · 2023Review
- Distributions of Platelet-Derived Growth Factor Receptor-α Positive Cells and Interstitial Cells of Cajal in the Colon of Rats with Diabetes Mellitus Type 2.Medicina (Kaunas, Lithuania) · 2023Article
- Structure of the myenteric plexus in normal and diseased human ileum analyzed by X-ray virtual histology slices.World journal of gastroenterology · 2022Article
- Telocytes and Macrophages in the Gut: From Morphology to Function, Do the Two Cell Types Interact with Each Other? Which Helps Which?International journal of molecular sciences · 2022Review
- Telocytes: An Emerging Component of Stem Cell Niche Microenvironment.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2021Review
- United European Gastroenterology (UEG) and European Society for Neurogastroenterology and Motility (ESNM) consensus on gastroparesis.United European gastroenterology journal · 2021Article
- Differentiated PDGFRα-Positive Cells: A Novel In-Vitro Model for Functional Studies of Neuronal Nitric Oxide Synthase.International journal of molecular sciences · 2021Article
- Gastric Biopsies in Gastroparesis: Insights into Gastric Neuromuscular Disorders to Aid Treatment.Gastroenterology clinics of North America · 2020Review
- The Telocytes: Ten Years after Their Introduction in the Scientific Literature. An Update on Their Morphology, Distribution, and Potential Roles in the Gut.International journal of molecular sciences · 2020Review
- Spatial relationship between telocytes, interstitial cells of Cajal and the enteric nervous system in the human ileum and colon.Journal of cellular and molecular medicine · 2020Article
- Transcriptome profiling reveals significant changes in the gastric muscularis externa with obesity that partially overlap those that occur with idiopathic gastroparesis.BMC medical genomics · 2019Article
- Gastroparesis is associated with decreased FOXF1 and FOXF2 in humans, and loss of FOXF1 and FOXF2 results in gastroparesis in mice.Neurogastroenterology and motility · 2019Article
- The Role of Prostaglandins in Disrupted Gastric Motor Activity Associated With Type 2 Diabetes.Diabetes · 2019Article
- Gastroparesis.Nature reviews. Disease primers · 2018Review
- Idiopathic gastroparesis is associated with specific transcriptional changes in the gastric muscularis externa.Neurogastroenterology and motility · 2018Article
- Effect of Hyperglycemia on Purinergic and Nitrergic Inhibitory Neuromuscular Transmission in the Antrum of the Stomach: Implications for Fast Gastric Emptying.Frontiers in medicine · 2018Article
- Regulation of Gastrointestinal Smooth Muscle Function by Interstitial Cells.Physiology (Bethesda, Md.) · 2016Review
- FAM96A is a novel pro-apoptotic tumor suppressor in gastrointestinal stromal tumors.International journal of cancer · 2015Article
- Temporal sequence of activation of cells involved in purinergic neurotransmission in the colon.The Journal of physiology · 2015Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
backgroundEmerging evidence suggests that "fibroblast-like cells" (FLC) may play a role in the regulation of gastrointestinal (GI) motor function. FLC are ultrastructurally distinct from other interstitial cells, including interstitial cells of Cajal (ICC), and express small-conductance Ca(2+) -activated K(+) channels (SK3). In mice, platelet-derived growth factor receptor α (PDGFRα) antibody has also been shown to label FLC. The aims of this study were to determine the morphology and distribution of PDGFRα-immunoreactive (ir) FLC in human gastric muscle and to determine if FLC are altered in gastroparesis, where ICC are reduced.
methodsFull thickness gastric body biopsies from five healthy subjects, 10 diabetic, and 10 idiopathic gastroparesis patients were immunolabeled using SK3 and PDGFRα staining for FLC and Kit staining for ICC. Intramuscular FLC and ICC were quantified. KEY
resultsIntramuscular PDGFRα-ir cells had slender cell bodies and long, thin processes and were more abundant in the longitudinal compared with the circular muscle. In the region of myenteric plexus, FLC had smaller, rounder cell bodies with 3-4 processes and formed networks, often around ganglia. All SK3-ir cell structures showed complete overlap with PDGFRα-ir. FLC were in close proximity to ICC, but their cell bodies did not overlap. No differences were seen in the distribution, morphology, or overall numbers of FLC in gastroparesis patients. CONCLUSIONS & INFERENCES: In conclusion, PDGFRα identifies FLC in human gastric smooth muscle. FLC were not altered in distribution or overall numbers in gastroparesis. Additional studies are required to determine their role in human GI function.
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