ArticleFrontiers in oncology2012
Pathogenic Role of the CRL4 Ubiquitin Ligase in Human Disease.
Article in Frontiers in oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 72 citations in OpenAlex.
- CSN-CRL Complexes: New Regulators of Adipogenesis.Biomolecules · 2025Review
- Functional genomics pipeline identifies CRL4 inhibition for the treatment of ovarian cancer.Clinical and translational medicine · 2025Article
- CUL4A silencing attenuates cervical carcinogenesis and improves Cisplatin sensitivity.Molecular and cellular biochemistry · 2024Article
- WDR5-HOTTIP Histone Modifying Complex Regulates Neural Migration and Dendrite Polarity of Pyramidal Neurons via Reelin Signaling.Molecular neurobiology · 2022Article
- CRL4-DCAF8L1 Regulates BRCA1 and BARD1 Protein Stability.International journal of biological sciences · 2022Article
- CUL4The American journal of pathology · 2021Article
- CRL4AOncogene · 2021Article
- CUL4B negatively regulates Toll-like receptor-triggered proinflammatory responses by repressing Pten transcription.Cellular & molecular immunology · 2021Article
- Upregulation of Cullin 4B Promotes Gastric Cancer and Predicts Poor Prognosis.OncoTargets and therapy · 2020Article
- Stabilization of E2-EPF UCP protein is implicated in hepatitis B virus-associated hepatocellular carcinoma progression.Cellular and molecular life sciences : CMLS · 2019Article
- Cul4a promotes zebrafish primitive erythropoiesis via upregulating scl and gata1 expression.Cell death & disease · 2019Article
- CUL4B promotes aggressive phenotypes of HNSCC via the activation of the Wnt/β-catenin signaling pathway.Cancer medicine · 2019Article
- The emerging role for Cullin 4 family of E3 ligases in tumorigenesis.Biochimica et biophysica acta. Reviews on cancer · 2019Review
- Role of HBx in hepatitis B virus persistence and its therapeutic implications.Current opinion in virology · 2018Review
- CUL4B promotes gastric cancer invasion and metastasis-involvement of upregulation of HER2.Oncogene · 2018Article
- Cul4B is a novel prognostic marker in cholangiocarcinoma.Oncology letters · 2017Article
- Guard the guardian: A CRL4 ligase stands watch over histone production.Nucleus (Austin, Tex.) · 2017Review
- Dysregulation of CUL4A and CUL4B Ubiquitin Ligases in Lung Cancer.The Journal of biological chemistry · 2017Article
- The role of cullin4B in human cancers.Experimental hematology & oncology · 2017Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The cullin 4-RING ubiquitin ligase (CRL4) family employs multiple DDB1-CUL4 associated factors substrate receptors to direct the degradation of proteins involved in a wide spectrum of cellular functions. Aberrant expression of the cullin 4A (CUL4A) gene is found in many tumor types, while mutations of the cullin 4B (CUL4B) gene are causally associated with human X-linked mental retardation. This focused review will summarize our current knowledge of the two CUL4 family members in the pathogenesis of human malignancy and neuronal disease, and discuss their potential as new targets for cancer prevention and therapeutic intervention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.