ArticlePloS one2012
Is promiscuity associated with enhanced selection on MHC-DQα in mice (genus Peromyscus)?
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sexual selection explains more functional variation in the mammalian major histocompatibility complex than parasitism.Proceedings. Biological sciences · 2013Pooled it
- Mating system is correlated with immunogenetic diversity in sympatric species of Peromyscine mice.PloS one · 2020Article
- Differential gene expression in relation to mating system in Peromyscine rodents.Ecology and evolution · 2019Article
- Physiological and biochemical changes associated with acute experimental dehydration in the desert adapted mouse,Physiological reports · 2017Article
- Peromyscus transcriptomics: Understanding adaptation and gene expression plasticity within and between species of deer mice.Seminars in cell & developmental biology · 2017Review
- Genetic Variation at Exon 2 of the MHC Class II DQB Locus in Blue Whale (Balaenoptera musculus) from the Gulf of California.PloS one · 2016Article
- Multiple paternity does not depend on male genetic diversity.Animal behaviour · 2014Article
- Genomic analysis of MHC-based mate choice in the monogamous California mouse.Behavioral ecology : official journal of the International Society for Behavioral EcologyArticle
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Reproductive behavior may play an important role in shaping selection on Major Histocompatibility Complex (MHC) genes. For example, the number of sexual partners that an individual has may affect exposure to sexually transmitted pathogens, with more partners leading to greater exposure and, hence, potentially greater selection for variation at MHC loci. To explore this hypothesis, we examined the strength of selection on exon 2 of the MHC-DQα locus in two species of Peromyscus. While the California mouse (P. californicus) is characterized by lifetime social and genetic monogamy, the deer mouse (P. maniculatus) is socially and genetically promiscuous; consistent with these differences in mating behavior, the diversity of bacteria present within the reproductive tracts of females is significantly greater for P. maniculatus. To test the prediction that more reproductive partners and exposure to a greater range of sexually transmitted pathogens are associated with enhanced diversifying selection on genes responsible for immune function, we compared patterns and levels of diversity at the Class II MHC-DQα locus in sympatric populations of P. maniculatus and P. californicus. Using likelihood based analyses, we show that selection is enhanced in the promiscuous P. maniculatus. This study is the first to compare the strength of selection in wild sympatric rodents with known differences in pathogen milieu.
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