Trial reportPloS one2012
Polymorphisms related to the serum 25-hydroxyvitamin D level and risk of myocardial infarction, diabetes, cancer and mortality. The Tromsø Study.
Trial report in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01395303 (Polymorphisms in the Vitamin D System and Health), which is not on this map. Cited by 51 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Polymorphisms in the Vitamin D System and Health
Who cites it
51 citing papers in PubMed, 5 syntheses or guidelines pooled it, 124 citations in OpenAlex.
- Vitamin D and human health: evidence from Mendelian randomization studies.European journal of epidemiology · 2024Pooled it
- A Bidirectional Mendelian Randomization Study to evaluate the causal role of reduced blood vitamin D levels with type 2 diabetes risk in South Asians and Europeans.Nutrition journal · 2021Pooled it
- Association of vitamin D with risk of type 2 diabetes: A Mendelian randomisation study in European and Chinese adults.PLoS medicine · 2018Pooled it
- Risk factors for type 2 diabetes mellitus: An exposure-wide umbrella review of meta-analyses.PloS one · 2018Pooled it
- Vitamin D metabolic loci and preeclampsia risk in multi-ethnic pregnant women.Physiological reports · 2018Pooled it
- Effect of Monthly High-Dose Vitamin D Supplementation on Cardiovascular Disease in the Vitamin D Assessment Study : A Randomized Clinical Trial.JAMA cardiology · 2017Trial
- Association between circulating 25-hydroxyvitamin D and incident type 2 diabetes: a mendelian randomisation study.The lancet. Diabetes & endocrinology · 2015Trial
- Trial
- Serum Vitamin D and Vaspin Levels Among Patients with Acute Myocardial Infarction and Their Association with Risk Factors.International journal of general medicine · 2024Article
- Article
- Higher Dietary Vitamin D Intake Influences the Lipid Profile and hs-CRP Concentrations: Cross-Sectional Assessment Based on The National Health and Nutrition Examination Survey.Life (Basel, Switzerland) · 2023Article
- Association of 25-hydroxyvitamin D with risk of overall and colorectal cancer among Japanese using a Mendelian randomization approach.Scientific reports · 2023Article
- Vitamin D Deficiency as an Independent Predictor of Myocardial Infarction in the Elderly.Archives of Razi Institute · 2021Article
- Dysregulation of vitamin D synthesis pathway genes in colorectal cancer: A case-control study.Journal of clinical laboratory analysis · 2021Article
- Next-generation epidemiology: the role of high-resolution molecular phenotyping in diabetes research.Diabetologia · 2020Review
- Vitamin D pathway-related gene polymorphisms and their association with metabolic diseases: A literature review.Journal of diabetes and metabolic disorders · 2020Review
- Vitamin D Supplementation for Prevention of Type 2 Diabetes Mellitus: To D or Not to D?The Journal of clinical endocrinology and metabolism · 2020Review
- Vitamin D in Type 2 Diabetes: Genetic Susceptibility and the Response to Supplementation.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2020Article
- Genetic Components of 25-Hydroxyvitamin D Increase in Three Randomized Controlled Trials.Journal of clinical medicine · 2020Article
- Effect of Genetically Low 25-Hydroxyvitamin D on Mortality Risk: Mendelian Randomization Analysis in 3 Large European Cohorts.Nutrients · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveLow serum 25(OH)D levels are associated with cardiovascular risk factors, and also predict future myocardial infarction (MI), type 2 diabetes (T2DM), cancer and all-cause mortality. Recently several single nucleotide polymorphisms (SNPs) associated with serum 25-hydroxyvitamin D (25(OH)D) level have been identified. If these relations are causal one would expect a similar association between these SNPs and health.
methodsDNA was prepared from subjects who participated in the fourth survey of the Tromsø Study in 1994-1995 and who were registered with the endpoints MI, T2DM, cancer or death as well as a randomly selected control group. The endpoint registers were complete up to 2007-2010. Genotyping was performed for 17 SNPs related to the serum 25(OH)D level.
resultsA total of 9528 subjects were selected for genetic analyses which were successfully performed for at least one SNP in 9471 subjects. Among these, 2025 were registered with MI, 1092 with T2DM, 2924 with cancer and 3828 had died. The mean differences in serum 25(OH)D levels between SNP genotypes with the lowest and highest serum 25(OH)D levels varied from 0.1 to 7.8 nmol/L. A genotype score based on weighted risk alleles regarding low serum 25(OH)D levels was established. There was no consistent association between the genotype score or individuals SNPs and MI, T2DM, cancer, mortality or risk factors for disease. However, for rs6013897 genotypes (located at the 24-hydroxylase gene (CYP24A1)) there was a significant association with breast cancer (P<0.05).
conclusionOur results do not support nor exclude a causal relationship between serum 25(OH)D levels and MI, T2DM, cancer or mortality, and our observation on breast cancer needs confirmation. Further genetic studies are warranted, particularly in populations with vitamin D deficiency.
trial registrationClinicalTrials.gov NCT01395303.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.