ArticlePloS one2012
Suppression of AP1 transcription factor function in keratinocyte suppresses differentiation.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Profiling and metaanalysis of epidermal keratinocytes responses to epidermal growth factor.BMC genomics · 2013Pooled it
- Fatty acid oxidation fuels mitochondrial respiration to drive epidermal stem cell fate and differentiation.Nature communications · 2026Article
- Squamous-state excursions activate APOBEC3A in cancer.bioRxiv : the preprint server for biology · 2026Article
- Retraction: Suppression of AP1 Transcription Factor Function in Keratinocyte Suppresses Differentiation.PloS one · 2021Article
- Kdm6b regulates context-dependent hematopoietic stem cell self-renewal and leukemogenesis.Leukemia · 2019Article
- Expression profiling and bioinformatic analyses suggest new target genes and pathways for human hair follicle related microRNAs.BMC dermatology · 2017Article
- Interleukin-4 Downregulation of Involucrin Expression in Human Epidermal Keratinocytes Involves Stat6 Sequestration of the Coactivator CREB-Binding Protein.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2016Article
- MEP50/PRMT5 Reduces Gene Expression by Histone Arginine Methylation and this Is Reversed by PKCδ/p38δ Signaling.The Journal of investigative dermatology · 2016Article
- PC-TraFF: identification of potentially collaborating transcription factors using pointwise mutual information.BMC bioinformatics · 2015Article
- AKT1-mediated Lamin A/C degradation is required for nuclear degradation and normal epidermal terminal differentiation.Cell death and differentiation · 2015Article
- Type II transglutaminase stimulates epidermal cancer stem cell epithelial-mesenchymal transition.Oncotarget · 2015Article
- Methylosome Protein 50 and PKCδ/p38δ Protein Signaling Control Keratinocyte Proliferation via Opposing Effects on p21Cip1 Gene Expression.The Journal of biological chemistry · 2015Article
- Suppressing AP1 factor signaling in the suprabasal epidermis produces a keratoderma phenotype.The Journal of investigative dermatology · 2015Article
- Efficient keratinocyte differentiation strictly depends on JNK-induced soluble factors in fibroblasts.The Journal of investigative dermatology · 2014Article
- Keratinocyte detachment-differentiation connection revisited, or anoikis-pityriasi nexus redux.PloS one · 2014Article
- Differentiation-associated genes regulated by c-Jun and decreased in the progression of esophageal squamous cell carcinoma.PloS one · 2014Article
- Modulation of keratin 1, 10 and involucrin expression as part of the complex response of the human keratinocyte cell line HaCaT to ultraviolet radiation.Interdisciplinary toxicology · 2013Article
- Dissecting the psoriasis transcriptome: inflammatory- and cytokine-driven gene expression in lesions from 163 patients.BMC genomics · 2013Article
- AP1 transcription factors in epidermal differentiation and skin cancer.Journal of skin cancer · 2013Article
- Article
Corrections and comments
- Retraction · 2021-02-11Concerns/Issues about Data · Concerns/Issues about Image · Falsification/Fabrication of Image · Investigation by Company/Institution · Manipulation of Images · · Richard L Eckert has ORI finding of misconduct: https://ori.hhs.gov/content/case-summary-eckert-richard-l;
- Commented on by
- Retracted
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Our previous study shows that inhibiting activator protein one (AP1) transcription factor function in murine epidermis, using dominant-negative c-jun (TAM67), increases cell proliferation and delays differentiation. To understand the mechanism of action, we compare TAM67 impact in mouse epidermis and in cultured normal human keratinocytes. We show that TAM67 localizes in the nucleus where it forms TAM67 homodimers that competitively interact with AP1 transcription factor DNA binding sites to reduce endogenous jun and fos factor binding. Involucrin is a marker of keratinocyte differentiation that is expressed in the suprabasal epidermis and this expression requires AP1 factor interaction at the AP1-5 site in the promoter. TAM67 interacts competitively at this site to reduce involucrin expression. TAM67 also reduces endogenous c-jun, junB and junD mRNA and protein level. Studies with c-jun promoter suggest that this is due to reduced transcription of the c-jun gene. We propose that TAM67 suppresses keratinocyte differentiation by interfering with endogenous AP1 factor binding to regulator elements in differentiation-associated target genes, and by reducing endogenous c-jun factor expression.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.