ArticlePloS one2012
Ontogeny of Toll-like and NOD-like receptor-mediated innate immune responses in Papua New Guinean infants.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 40 citations in OpenAlex.
- Trial
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- Strategies for active and passive pediatric RSV immunization.Therapeutic advances in vaccines and immunotherapy · 2021Review
- Increased T Cell Differentiation and Cytolytic Function in Bangladeshi Compared to American Children.Frontiers in immunology · 2019Article
- Cytokine profiling in healthy children shows association of age with cytokine concentrations.Scientific reports · 2017Article
- Influence of Age and Other Factors on Cytokine Expression Profiles in Healthy Children-A Systematic Review.Frontiers in pediatrics · 2017Article
- Postnatal Innate Immune Development: From Birth to Adulthood.Frontiers in immunology · 2017Review
- Influenza A Virus Infection, Innate Immunity, and Childhood.JAMA pediatrics · 2015Review
- Factors influencing innate immunity and vaccine responses in infancy.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Exposure to mercury and aluminum in early life: developmental vulnerability as a modifying factor in neurologic and immunologic effects.International journal of environmental research and public health · 2015Review
- Single-cell analysis of innate cytokine responses to pattern recognition receptor stimulation in children across four continents.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Ontogeny of early life immunity.Trends in immunology · 2014Review
- Altered innate immune development in HIV-exposed uninfected infants.Journal of acquired immune deficiency syndromes (1999) · 2014Article
- Pattern recognition receptor-mediated cytokine response in infants across 4 continents.The Journal of allergy and clinical immunology · 2014Article
- The role of environmental factors in modulating immune responses in early life.Frontiers in immunology · 2014Review
- Listeria monocytogenes: a promising vehicle for neonatal vaccination.Human vaccines & immunotherapeutics · 2014Review
- Malaria modifies neonatal and early-life toll-like receptor cytokine responses.Infection and immunity · 2013Article
- Heterologous ("nonspecific") and sex-differential effects of vaccines: epidemiology, clinical trials, and emerging immunologic mechanisms.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2013Review
- Review
- Role of innate immunity in neonatal infection.American journal of perinatology · 2013Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Studies addressing the ontogeny of the innate immune system in early life have reported mainly on Toll-like receptor (TLR) responses in infants living in high-income countries, with little or even no information on other pattern recognition receptors or on early life innate immune responses in children living under very different environmental conditions in less-developed parts of the world. In this study, we describe whole blood innate immune responses to both Toll-like and nucleotide-binding oligomerization domain (NOD)-like receptor agonists including the widely used vaccine adjuvant 'alum' in a group of Papua New Guinean infants aged 1-3 (n = 18), 4-6 (n = 18), 7-12 (n = 21) and 13-18 (n = 10) months old. Depending on the ligands and cytokines studied, different age-related patterns were found: alum-induced IL-1β and CXCL8 responses were found to significantly decline with increasing age; inflammatory (IL-6, IL-1β, IFN-γ) responses to TLR2 and TLR3 agonists increased; and IL-10 responses remained constant or increased during infancy, while TNF-α responses either declined or remained the same. We report for the first time that whole blood innate immune responses to the vaccine adjuvant alum decrease with age in infancy; a finding that may imply that the adjuvant effect of alum in pediatric vaccines could be age-related. Our findings further suggest that patterns of innate immune development may vary between geographically diverse populations, which in line with the 'hygiene hypothesis' particularly involves persistence of innate IL-10 responses in populations experiencing higher infectious pressure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.