ArticlePloS one2012
Long-term health outcomes in children born to mothers with diabetes: a population-based cohort study.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Maternal Body Mass Index, Diabetes, and Gestational Weight Gain and Risk for Pediatric Cancer in Offspring: A Systematic Review and Meta-Analysis.JNCI cancer spectrum · 2022Pooled it
- Risks of specific congenital anomalies in offspring of women with diabetes: A systematic review and meta-analysis of population-based studies including over 80 million births.PLoS medicine · 2022Pooled it
- Maternal diabetes and risk of childhood malignancies in the offspring: a systematic review and meta-analysis of observational studies.Acta diabetologica · 2021Pooled it
- Prenatal exposure to gestational diabetes mellitus increases developmental defects in the enamel of offspring.PloS one · 2019Trial
- Psychosocial adversity and socioeconomic position during childhood and epigenetic age: analysis of two prospective cohort studies.Human molecular genetics · 2018Trial
- Article
- Gestational Diabetes Mellitus: New Thinking on Diagnostic Criteria.Life (Basel, Switzerland) · 2024Review
- Increased purchases of prescription medicines in offspring of women with type 1 diabetes: a Finnish register-based cohort study between 1995 and 2018.Annals of medicine · 2024Article
- Assessment of the Validity of Administrative Data for Gestational Diabetes Ascertainment.American journal of obstetrics & gynecology MFM · 2023Article
- Maternal diabetes and childhood cancer risks in offspring: two population-based studies.British journal of cancer · 2022Article
- Proteomics and bioinformatics analysis of cardiovascular related proteins in offspring exposed to gestational diabetes mellitus.Frontiers in cardiovascular medicine · 2022Article
- Enablers and barriers for women with gestational diabetes mellitus to achieve optimal glycaemic control - a qualitative study using the theoretical domains framework.BMC pregnancy and childbirth · 2018Article
- Maternal diabetes and risk of childhood acute lymphoblastic leukaemia in the offspring.British journal of cancer · 2018Article
- Maternal diabetes and incidence of childhood cancer - a nationwide cohort study and exploratory genetic analysis.Clinical epidemiology · 2017Article
- Sex-Differences in the Metabolic Health of Offspring of Parents with Diabetes: A Record-Linkage Study.PloS one · 2015Article
- Epigenetics and life-long consequences of an adverse nutritional and diabetic intrauterine environment.Reproduction (Cambridge, England) · 2014Review
- Perinatal outcomes in type 2 diabetes.Current diabetes reports · 2014Review
- Association between hyperglycemia in middle and late pregnancy and maternal-fetal outcomes: a retrospective study.BMC pregnancy and childbirth · 2014Article
- DNA damage and its cellular response in mother and fetus exposed to hyperglycemic environment.BioMed research international · 2014Review
- Epigenetics of gestational diabetes mellitus and offspring health: the time for action is in early stages of life.Molecular human reproduction · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo examine whether prenatal exposure to parental type 1 diabetes, type 2 diabetes, or gestational diabetes is associated with an increased risk of malignant neoplasm or diseases of the circulatory system in the offspring. METHODS/PRINCIPAL
findingsWe conducted a population-based cohort study of 1,781,576 singletons born in Denmark from 1977 to 2008. Children were followed for up to 30 years from the day of birth until the onset of the outcomes under study, death, emigration, or December 31, 2009, whichever came first. We used Cox proportional hazards model to estimate hazard ratios (HR) with 95% confidence intervals (95% CI) for the outcomes under study while adjusting for potential confounders. An increased risk of malignant neoplasm was found in children prenatally exposed to maternal type 2 diabetes (HR = 2.2, 95%CI: 1.5-3.2). An increased risk of diseases of the circulatory system was found in children exposed to maternal type 1 diabetes (HR = 2.2, 95%CI: 1.6-3.0), type 2 diabetes (HR = 1.4, 95%CI: 1.1-1.7), and gestational diabetes (HR = 1.3, 95%CI: 1.1-1.6), but results were attenuated after excluding children with congenital malformations. An increased risk of diseases of the circulatory system was also found in children exposed to paternal type 2 diabetes (HR = 1.5, 95%CI: 1.1-2.2) and the elevated risk remained after excluding children with congenital malformations.
conclusionsThis study suggests that susceptibility to malignant neoplasm is modified partly by fetal programming. Diseases of the circulatory system may be modified by genetic factors, other time-stable family factors, or fetal programming.
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