ArticleFrontiers in endocrinology2012
Sense and nonsense in metabolic control of reproduction.
Article in Frontiers in endocrinology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 30 citations in OpenAlex.
- Metabolic hormones are integral regulators of female reproductive health and function.Bioscience reports · 2024Review
- The Sexual Dimorphism of Human Adipose Depots.Biomedicines · 2022Review
- Disruption of energy homeostasis by food restriction or high ambient temperature exposure affects gonadal function in male house finches (Haemorhous mexicanus).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2020Article
- Food restriction-induced changes in motivation differ with stages of the estrous cycle and are closely linked to RFamide-related peptide-3 but not kisspeptin in Syrian hamsters.Physiology & behavior · 2018Article
- RFamide-related Peptide-3 and the Trade-off between Reproductive and Ingestive Behavior.Integrative and comparative biology · 2017Article
- Metabolic stressors and signals differentially affect energy allocation between reproduction and immune function.General and comparative endocrinology · 2014Article
- Energy Balance Regulating Neuropeptides Are Expressed through Pregnancy and Regulated by Interleukin-6 Deficiency in Mouse Placenta.International journal of endocrinology · 2014Article
- Sex differences in the physiology of eating.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Review
- Neuroendocrine regulation of appetitive ingestive behavior.Frontiers in neuroscience · 2013Review
- Environmental and social influences on neuroendocrine puberty and behavior in macaques and other nonhuman primates.Hormones and behavior · 2013Review
- From precocious puberty to infertility: metabolic control of the reproductive function.Frontiers in endocrinology · 2013Article
- Nutrient-dependent/pheromone-controlled adaptive evolution: a model.Socioaffective neuroscience & psychology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An exciting synergistic interaction occurs among researchers working at the interface of reproductive biology and energy homeostasis. Reproductive biologists benefit from the theories, experimental designs, and methodologies used by experts on energy homeostasis while they bring context and meaning to the study of energy homeostasis. There is a growing recognition that identification of candidate genes for obesity is little more than meaningless reductionism unless those genes and their expression are placed in a developmental, environmental, and evolutionary context. Reproductive biology provides this context because metabolic energy is the most important factor that controls reproductive success and gonadal hormones affect energy intake, storage, and expenditure. Reproductive hormone secretion changes during development, and reproductive success is key to evolutionary adaptation, the process that most likely molded the mechanisms that control energy balance. It is likely that by viewing energy intake, storage, and expenditure in the context of reproductive success, we will gain insight into human obesity, eating disorders, diabetes, and other pathologies related to fuel homeostasis. This review emphasizes the metabolic hypothesis: a sensory system monitors the availability of oxidizable metabolic fuels and orchestrates behavioral motivation to optimize reproductive success in environments where energy availability fluctuates or is unpredictable.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.