ArticleFrontiers in endocrinology2011
Therapeutic prospects of metabolically active brown adipose tissue in humans.
Article in Frontiers in endocrinology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Impact of skeletal muscle mass index on glycemic progression and remission in Chinese adults with prediabetes: a nationwide cohort study.European journal of medical research · 2025Article
- The Notch-PDGFRβ axis suppresses brown adipocyte progenitor differentiation in early post-natal mice.Developmental cell · 2024Article
- Supraclavicular brown adipocytes originate from Tbx1+ myoprogenitors.PLoS biology · 2023Article
- Fabricating 3-dimensional human brown adipose microtissues for transplantation studies.Bioactive materials · 2023Article
- Multi-organ FGF21-FGFR1 signaling in metabolic health and disease.Frontiers in cardiovascular medicine · 2022Review
- Adaptive thermogenesis in brown adipose tissue involves activation of pannexin-1 channels.Molecular metabolism · 2021Article
- Developmental and functional heterogeneity of thermogenic adipose tissue.Journal of molecular cell biology · 2020Review
- Targeting thermogenesis in brown fat and muscle to treat obesity and metabolic disease.Nature reviews. Endocrinology · 2018Review
- Coordinated regulation of hepatic and adipose tissue transcriptomes by the oral administration of an amino acid mixture simulating the larval saliva of Vespa species.Genes & nutrition · 2016Article
- Comprehensive molecular characterization of human adipocytes reveals a transient brown phenotype.Journal of translational medicine · 2015Article
- Fibroblast Growth Factor Signaling in Metabolic Regulation.Frontiers in endocrinology · 2015Review
- Article
- Brown adipose tissue biology and therapeutic potential.Frontiers in endocrinology · 2013Article
- PAZ6 cells constitute a representative model for human brown pre-adipocytes.Frontiers in endocrinology · 2012Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The world-wide obesity epidemic constitutes a severe threat to human health and wellbeing and poses a major challenge to health-care systems. Current therapeutic approaches, relying mainly on reduced energy intake and/or increased exercise energy expenditure, are generally of limited effectiveness. Previously believed to be present only in children, the existence of metabolically active brown adipose tissue (BAT) was recently demonstrated also in healthy human adults. The physiological role of BAT is to dissipate chemical energy, mainly from fatty acids, as heat to maintain body temperature in cold environments. Recent studies indicate that the activity of BAT is negatively correlated with overweight and obesity, findings that raise the exciting possibility of new and effective weight reduction therapies based on increased BAT energy expenditure, a process likely to be amenable to pharmacological intervention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.