Evidence map›Paper›PMID 22649378›Full record

ArticleFrontiers in endocrinology2011

The ventral premammillary nucleus links metabolic cues and reproduction.

Jose Donato, Carol Fuzeti Elias

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.3field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 45 citations in OpenAlex.

  1. CART Neurons in the Hypothalamic Ventral Premammillary Nucleus (PMv) in Rats Mediate Maternal, But Not Inter-male Aggression.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
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  14. The role of leptin in health and disease.Temperature (Austin, Tex.) · 2017
    Review
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  18. A critical view of the use of genetic tools to unveil neural circuits: the case of leptin action in reproduction.American journal of physiology. Regulatory, integrative and comparative physiology · 2014
    Review
  19. Article
  20. Agouti-related peptide plays a critical role in leptin's effects on female puberty and reproduction.American journal of physiology. Endocrinology and metabolism · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jose DonatoDivision of Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center Dallas, TX, USA.
Carol Fuzeti Elias
The University of Texas Southwestern Medical Center · US

Funding

Role of leptin-mediated PI3 Kinase signaling on reproductive controlR01HD061539 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI ELIAS, CAROL FUZETI · 2009 to 2013
$1.6M
NICHD NIH HHS R01 HD061539
6 · The paper itself

Abstract

The amount of body fat and the energy balance are important factors that influence the timing of puberty and the normal reproductive function. Leptin is a key hormone that conveys to the central nervous system information about the individual energy reserve and modulates the hypothalamus-pituitary-gonad (HPG) axis. Recent findings suggest that the ventral premammillary nucleus (PMV) mediates the effects of leptin as a permissive factor for the onset of puberty and the coordinated secretion of luteinizing hormone during conditions of negative energy balance. In this review, we will summarize the existing literature about the potential role played by PMV neurons in the regulation of the HPG axis.

Indexed as

adiposityGnRHhypothalamusleptinluteinizing hormonepuberty

Identifiers

PMID22649378
PMCPMC3355867
OpenAlexW2007013969

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.