Evidence map›Paper›PMID 22649372›Full record

ArticleFrontiers in endocrinology2011

Developments in the imaging of brown adipose tissue and its associations with muscle, puberty, and health in children.

Houchun H Hu, Vicente Gilsanz

Abstract read
In one paragraph

Article in Frontiers in endocrinology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Trial
  2. Effects of exercise on brown and beige adipocytes.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2019
    Review
  3. Article
  4. Article
  5. Article
  6. Molecular imaging of brown adipose tissue in health and disease.European journal of nuclear medicine and molecular imaging · 2014
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Houchun H HuDepartments of Radiology and Pediatrics, Children's Hospital of Los Angeles, Keck School of Medicine, University of Southern California Los Angeles, CA, USA.
Vicente Gilsanz

Funding

EXPANDING THE APPLICATION OF MRI FOR BODY FAT STUDIES IN HUMANSK25DK087931 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HU, HOUCHUN H. · 2010 to 2013
$543k
Quantification of Brown Adipose Tissue by MRI in Children and TeenagersR21DK090778 · NIDDK · CHILDREN'S HOSPITAL OF LOS ANGELES · PI GILSANZ, VICENTE · 2010 to 2011
$404k
NIDDK NIH HHS K25 DK087931NIDDK NIH HHS R21 DK090778
6 · The paper itself

Abstract

Fusion positron emission and computed tomography (PET/CT) remains the gold-standard imaging modality to non-invasively study metabolically active brown adipose tissue (BAT). It has been widely applied to studies in adult cohorts. In contrast, the number of BAT studies in children has been few. This is largely limited by the elevated risk of ionizing radiation and radionuclide tracer usage by PET/CT and the ethical restriction of performing such exams on healthy children. However, metabolically active BAT has a significantly higher prevalence in pediatric patients, according to recent literature. Young cohorts thus represent an ideal population to examine the potential relationships of BAT to muscle development, puberty, disease state, and the accumulation of white adipose tissue. In turn, magnetic resonance imaging (MRI) represents the most promising modality to overcome the limitations of PET/CT. The development of rapid, repeatable MRI techniques to identify and quantify both metabolically active and inactive BAT non-invasively and without the use of exogenous contrast agents or the need for sedation in pediatric patients are critically needed to advance our knowledge of this tissue's physiology.

Indexed as

brown adipose tissuechildrenHounsfield unitsMRImusclePET/CTpubertywhite adipose tissue

Identifiers

PMID22649372
PMCPMC3355993

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.