ArticleFrontiers in endocrinology2011
Gonadotropin-releasing hormone and adipokinetic hormone signaling systems share a common evolutionary origin.
Article in Frontiers in endocrinology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Evolutionary conserved peptide and glycoprotein hormone-like neuroendocrine systems in C. elegans.Molecular and cellular endocrinology · 2024Article
- GnRH-Related Neurohormones in the Fruit FlyInternational journal of molecular sciences · 2021Review
- RPamide neuropeptides NLP-22 and NLP-2 act through GnRH-like receptors to promote sleep and wakefulness in C. elegans.Scientific reports · 2020Article
- Corazonin signaling integrates energy homeostasis and lunar phase to regulate aspects of growth and sexual maturation inProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Evolution of neuropeptide signalling systems.The Journal of experimental biology · 2018Review
- The evolution of neuropeptide signalling: insights from echinoderms.Briefings in functional genomics · 2017Review
- Identification of prohormones and pituitary neuropeptides in the African cichlid, Astatotilapia burtoni.BMC genomics · 2016Article
- Urbilaterian origin of paralogous GnRH and corazonin neuropeptide signalling pathways.Scientific reports · 2016Article
- Transcriptomic identification of starfish neuropeptide precursors yields new insights into neuropeptide evolution.Open biology · 2016Article
- Farnesol-like endogenous sesquiterpenoids in vertebrates: the probable but overlooked functional "inbrome" anti-aging counterpart of juvenile hormone of insects?Frontiers in endocrinology · 2014Review
- Diversity of the RFamide Peptide Family in Mollusks.Frontiers in endocrinology · 2014Review
- Hypothalamic-pituitary-gonadal endocrine system in the hagfish.Frontiers in endocrinology · 2013Review
- Global view of the evolution and diversity of metazoan neuropeptide signaling.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- GPCR Heterodimerization in the Reproductive System: Functional Regulation and Implication for Biodiversity.Frontiers in endocrinology · 2013Article
- Review
- Neuropeptide GPCRs in C. elegans.Frontiers in endocrinology · 2012Article
- More than two decades of research on insect neuropeptide GPCRs: an overview.Frontiers in endocrinology · 2012Article
- Molecular Coevolution of Neuropeptides Gonadotropin-Releasing Hormone and Kisspeptin with their Cognate G Protein-Coupled Receptors.Frontiers in neuroscience · 2012Article
Corrections and comments
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6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gonadotropin-releasing hormone (GnRH) is a critical and central hormone that regulates vertebrate reproduction. The high conservation of GnRH signaling within the chordates (deuterostomians) raises the important question as to whether its appearance might date back prior to the divergence of protostomian and deuterostomian lineages, about 700 million years ago. This leads to several important questions regarding the evolution of the GnRH family. Has GnRH been retained in most protostomian lineages? And was regulation of reproduction already a function of ancestral GnRH? The first question can undoubtedly be answered affirmatively since several GnRH-like sequences have been found in wide variety of protostomian and deuterostomian phyla. However, based on their different primary functions in different phyla - which implies a less unanimous answer on the second question - consistency in the nomenclature of this peptide family has been lost. A comparative and phylogenetic approach shows that the ecdysozoan adipokinetic hormones (AKHs), lophotrochozoan GnRHs and chordate GnRHs are structurally related and suggests that they all originate from a common ancestor. This review supports the view that the AKH-GnRH signaling system probably arose very early in metazoan evolution, prior to the divergence of protostomians and deuterostomians.
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