ArticleCase reports in gastroenterology2012
Liver Transplantation because of Acute Liver Failure due to Heme Arginate Overdose in a Patient with Acute Intermittent Porphyria.
Article in Case reports in gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 32 citations in OpenAlex.
- Teaching an old drug new tricks: Regulatory insights for the repurposing of hemin in cardiovascular disease.Pharmacology research & perspectives · 2024Review
- Cutting-Edge Therapies and Novel Strategies for Acute Intermittent Porphyria: Step-by-Step towards the Solution.Biomedicines · 2022Review
- The acute hepatic porphyrias.Translational gastroenterology and hepatology · 2021Review
- Plasma heme-induced renal toxicity is related to a capillary rarefaction.Scientific reports · 2017Article
- Hepatic porphyria: A narrative review.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2016Review
- Liver transplantation for pediatric inherited metabolic disorders: Considerations for indications, complications, and perioperative management.Pediatric transplantation · 2016Review
- Liver Fibrosis Associated with Iron Accumulation Due to Long-Term Heme-Arginate Treatment in Acute Intermittent Porphyria: A Case Series.JIMD reports · 2016Article
- Acute Hepatic Porphyria.Journal of clinical and translational hepatology · 2015Review
- Audit of the Use of Regular Haem Arginate Infusions in Patients with Acute Porphyria to Prevent Recurrent Symptoms.JIMD reports · 2015Article
- Liver transplantation in the management of porphyria.Hepatology (Baltimore, Md.) · 2014Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In acute attacks of acute intermittent porphyria, the mainstay of treatment is glucose and heme arginate administration. We present the case of a 58-year-old patient with acute liver failure requiring urgent liver transplantation after erroneous 6-fold overdose of heme arginate during an acute attack. As recommended in the product information, albumin and charcoal were administered and hemodiafiltration was started, which could not prevent acute liver failure, requiring super-urgent liver transplantation after 6 days. The explanted liver showed no preexisting liver cirrhosis, but signs of subacute liver injury and starting regeneration. The patient recovered within a short time. A literature review revealed four poorly documented cases of potential hepatic and/or renal toxicity of hematin or heme arginate. This is the first published case report of acute liver failure requiring super-urgent liver transplantation after accidental heme arginate overdose. The literature and recommendations in case of heme arginate overdose are summarized. Knowledge of a potentially fatal course is important for the management of future cases. If acute liver failure in case of heme arginate overdose is progressive, super-urgent liver transplantation has to be evaluated.
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