ArticlePlant physiology2012
Characterization of a glucosyltransferase enzyme involved in the formation of kaempferol and quercetin sophorosides in Crocus sativus.
Article in Plant physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 66 citations in OpenAlex.
- Loss of flavonol 3-O-glucosyltransferase activity confers soybean resistance to leaf-chewing insects.The Plant journal : for cell and molecular biology · 2026Article
- Review
- Functional, Nutraceutical and Health Endorsing Perspectives of Saffron.Food science & nutrition · 2025Review
- Functional Characterization of 5-International journal of molecular sciences · 2025Article
- Review
- The Pharmacological Activities ofOxidative medicine and cellular longevity · 2022Review
- Crocus transcription factors CstMYB1 and CstMYB1R2 modulate apocarotenoid metabolism by regulating carotenogenic genes.Plant molecular biology · 2021Article
- Arachis hypogaea resveratrol synthase 3 alters the expression pattern of UDP-glycosyltransferase genes in developing rice seeds.PloS one · 2021Article
- Complete Biosynthesis of the Anti-Diabetic Plant Metabolite Montbretin A.Plant physiology · 2020Article
- The Tapetal Major Facilitator NPF2.8 Is Required for Accumulation of Flavonol Glycosides on the Pollen Surface inThe Plant cell · 2020Article
- Bioaccessibility and Pharmacokinetics of a Commercial Saffron (Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Full-length transcriptome sequencing provides insights into the evolution of apocarotenoid biosynthesis inComputational and structural biotechnology journal · 2020Article
- Biosynthesis of the anti-diabetic metabolite montbretin A: glucosylation of the central intermediate mini-MbA.The Plant journal : for cell and molecular biology · 2019Article
- Candidate Enzymes for Saffron Crocin Biosynthesis Are Localized in Multiple Cellular Compartments.Plant physiology · 2018Article
- Functional Characterization ofThe Journal of biological chemistry · 2017Article
- Transcriptome-Guided Mining of Genes Involved in Crocin Biosynthesis.Frontiers in plant science · 2017Article
- Natural variation in flavonol accumulation in Arabidopsis is determined by the flavonol glucosyltransferase BGLU6.Journal of experimental botany · 2016Article
- Glycosylation Is a Major Regulator of Phenylpropanoid Availability and Biological Activity in Plants.Frontiers in plant science · 2016Review
- Article
- Biochemical and Molecular Characterization of a Flavonoid 3-O-glycosyltransferase Responsible for Anthocyanins and Flavonols Biosynthesis in Freesia hybrida.Frontiers in plant science · 2016Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
UGT707B1 is a new glucosyltransferase isolated from saffron (Crocus sativus) that localizes to the cytoplasm and the nucleus of stigma and tepal cells. UGT707B1 transcripts were detected in the stigma tissue of all the Crocus species analyzed, but expression analysis of UGT707B1 in tepals revealed its absence in certain species. The analysis of the glucosylated flavonoids present in Crocus tepals reveals the presence of two major flavonoid compounds in saffron: kaempferol-3-O-β-D-glucopyranosyl-(1-2)-β-D-glucopyranoside and quercetin-3-O-β-D-glucopyranosyl-(1-2)-β-D-glucopyranoside, both of which were absent from the tepals of those Crocus species that did not express UGT707B1. Transgenic Arabidopsis (Arabidopsis thaliana) plants constitutively expressing UGT707B1 under the control of the cauliflower mosaic virus 35S promoter have been constructed and their phenotype analyzed. The transgenic lines displayed a number of changes that resembled those described previously in lines where flavonoid levels had been altered. The plants showed hyponastic leaves, a reduced number of trichomes, thicker stems, and flowering delay. Levels of flavonoids measured in extracts of the transgenic plants showed changes in the composition of flavonols when compared with wild-type plants. The major differences were observed in the extracts from stems and flowers, with an increase in 3-sophoroside flavonol glucosides. Furthermore, a new compound not detected in ecotype Columbia wild-type plants was detected in all the tissues and identified as kaempferol-3-O-sophoroside-7-O-rhamnoside. These data reveal the involvement of UGT707B1 in the biosynthesis of flavonol-3-O-sophorosides and how significant changes in flavonoid homeostasis can be caused by the overproduction of a flavonoid-conjugating enzyme.
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