ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Enhanced synaptic integration of adult-born neurons in the olfactory bulb of lactating mothers.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 63 citations in OpenAlex.
- Layer-specific variation in intracellular GABA immunoreactivity in the neuronal organization of the mouse main olfactory bulb.Cell and tissue research · 2026Article
- A time-series transcriptomic dataset of the mouse olfactory bulb across pregnancy and lactation.Scientific data · 2026Article
- New Neurons in the Postnatal Olfactory System: Functions in the Healthy and Regenerating Brain.Brain sciences · 2025Review
- Adult neurogenesis and the microbiota-gut-brain axis in farm animals: underestimated and understudied parameters for improving welfare in livestock farming.Frontiers in neuroscience · 2024Review
- Less can be more: Fine tuning the maternal brain.Neuroscience and biobehavioral reviews · 2022Review
- The Onset of Maternal Behavior in Sheep and Goats: Endocrine, Sensory, Neural, and Experiential Mechanisms.Advances in neurobiology · 2022Article
- Pregnancy Promotes Maternal Hippocampal Neurogenesis in Guinea Pigs.Neural plasticity · 2019Article
- Cortical thickness variation of the maternal brain in the first 6 months postpartum: associations with parental self-efficacy.Brain structure & function · 2018Article
- Genetic tagging of active neurons in auditory cortex reveals maternal plasticity of coding ultrasonic vocalizations.Nature communications · 2018Article
- The role of microglia and their CX3CR1 signaling in adult neurogenesis in the olfactory bulb.eLife · 2017Article
- Functional Plasticity of Odor Representations during Motherhood.Cell reports · 2017Article
- Integrating Hebbian and homeostatic plasticity: the current state of the field and future research directions.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Article
- Different forms of structural plasticity in the adult olfactory bulb.Neurogenesis (Austin, Tex.) · 2017Review
- Adult Neurogenesis in Sheep: Characterization and Contribution to Reproduction and Behavior.Frontiers in neuroscience · 2017Review
- Plasticity in the olfactory bulb of the maternal mouse is prevented by gestational stress.Scientific reports · 2016Article
- Principal cell activity induces spine relocation of adult-born interneurons in the olfactory bulb.Nature communications · 2016Article
- Adult Olfactory Bulb Neurogenesis.Cold Spring Harbor perspectives in biology · 2016Review
- Persistent Structural Plasticity Optimizes Sensory Information Processing in the Olfactory Bulb.Neuron · 2016Article
- The birth of new neurons in the maternal brain: Hormonal regulation and functional implications.Frontiers in neuroendocrinology · 2016Review
- Neural control of maternal and paternal behaviors.Science (New York, N.Y.) · 2014Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One of the most dramatic events during the life of adult mammals is the transition into motherhood. This transition is accompanied by specific maternal behaviors, displayed by the mother, that ensure the survival and the well-being of her offspring. The execution of these behaviors is most likely accompanied by plastic changes in specific neuronal circuits, but these are still poorly defined. In this work, we studied the mammalian olfactory bulb (OB), which has been shown to be an essential brain region for maternal behaviors in mice. In the OB, we focused on adult-born neurons, which are continuously incorporated into the circuit during adulthood, thus providing a potential substrate for heightened plasticity after parturition. We analyzed the dynamics and morphological characteristics of adult-born granule cells (abGCs), innervating the OB of primiparous lactating mothers, shortly after parturition as well as in naive females. In vivo time-lapse imaging of abGCs revealed that dendritic spines were significantly more stable in lactating mothers compared with naive virgins. In contrast, spine stability of resident GCs remained unchanged after parturition. In addition, while spine size distribution of abGCs was approximately similar between mothers and naive virgins, the spine density of abGCs was lower in lactating mothers and the density of their presynaptic components was higher. These structural features are indicative of enhanced integration of adult-born neurons into the bulbar circuitry of lactating mothers. This enhanced integration may serve as a cellular mechanism, supporting changes in olfactory coding of new mothers during their first days following parturition.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.