ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Altered distribution of juxtaparanodal kv1.2 subunits mediates peripheral nerve hyperexcitability in type 2 diabetes mellitus.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Modulation of ion channels as emerging therapeutic targets in the treatment of diabetic neuropathy.EXCLI journal · 2026Review
- New High-Affinity Peptide Ligands for Kv1.2 Channel: Selective Blockers and Fluorescent Probes.Cells · 2024Article
- Traumatic and Diabetic Schwann Cell Demyelination Is Triggered by a Transient Mitochondrial Calcium Release through Voltage Dependent Anion Channel 1.Biomedicines · 2022Article
- Assembly and Function of the Juxtaparanodal Kv1 Complex in Health and Disease.Life (Basel, Switzerland) · 2020Review
- Early sensory neurophysiological changes in prediabetes.Journal of diabetes investigation · 2020Article
- Diabetic neuropathy.Nature reviews. Disease primers · 2019Article
- In vitro models to study insulin and glucocorticoids modulation of trimethyltin (TMT)-induced neuroinflammation and neurodegeneration, and in vivo validation in db/db mice.Archives of toxicology · 2019Article
- Nicotinate-curcumin ameliorates cognitive impairment in diabetic rats by rescuing autophagic flux in CA1 hippocampus.CNS neuroscience & therapeutics · 2019Article
- Type 2 Diabetes Leads to Axon Initial Segment Shortening inFrontiers in cellular neuroscience · 2018Article
- Chronic peripheral nerve compression disrupts paranodal axoglial junctions.Muscle & nerve · 2017Article
- Review
- Article
- NaJournal of neurogastroenterology and motility · 2016Article
- RhoA/rock signaling mediates peroxynitrite-induced functional impairment of Rat coronary vessels.BMC cardiovascular disorders · 2016Article
- Blocking mitochondrial calcium release in Schwann cells prevents demyelinating neuropathies.The Journal of clinical investigation · 2016Article
- Physiological and pathological functions of mechanosensitive ion channels.Molecular neurobiology · 2014Review
- The role of sodium channels in painful diabetic and idiopathic neuropathy.Current diabetes reports · 2014Review
- Article
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Peripheral nerve hyperexcitability (PNH) is one of the distal peripheral neuropathy phenotypes often present in patients affected by type 2 diabetes mellitus (T2DM). Through in vivo and ex vivo electrophysiological recordings in db/db mice, a model of T2DM, we observed that, in addition to reduced nerve conduction velocity, db/db mice also develop PNH. By using pharmacological inhibitors, we demonstrated that the PNH is mediated by the decreased activity of K(v)1-channels. In agreement with these data, we observed that the diabetic condition led to a reduced presence of the K(v)1.2-subunits in juxtaparanodal regions of peripheral nerves in db/db mice and in nerve biopsies from T2DM patients. Together, these observations indicate that the T2DM condition leads to potassium channel-mediated PNH, thus identifying them as a potential drug target to treat some of the DPN related symptoms.
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