ArticleBiology of reproduction2012
Slc2a8 deficiency in mice results in reproductive and growth impairments.
Article in Biology of reproduction, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
- Targeting hepatocyte-specific SLC2A8 blocks hepatic steatosis and dissociates TCA cycle flux inhibition from glutamine anaplerosis.Hepatology communications · 2025Article
- Genetic Animal Models of Cardiovascular Pathologies.Biomedicines · 2025Review
- Glucose metabolism and endometrium decidualization.Frontiers in endocrinology · 2025Review
- Neurodevelopment Is Dependent on Maternal Diet: Placenta and Brain Glucose Transporters GLUT1 and GLUT3.Nutrients · 2024Review
- QTLs and Candidate Genes Associated with Semen Traits in Merino Sheep.Animals : an open access journal from MDPI · 2023Article
- Review
- High-Fat Diet and Female Fertility across Lifespan: A Comparative Lesson from Mammal Models.Nutrients · 2022Review
- Role of Placental Glucose Transporters in Determining Fetal Growth.Reproductive sciences (Thousand Oaks, Calif.) · 2022Review
- An Update on the Progress of Endometrial Receptivity in Women with Polycystic Ovary Syndrome.Reproductive sciences (Thousand Oaks, Calif.) · 2022Review
- Differential Expression of Glucose Transporter Proteins GLUT-1, GLUT-3, GLUT-8 and GLUT-12 in the Placenta of Macrosomic, Small-for-Gestational-Age and Growth-Restricted Foetuses.Journal of clinical medicine · 2021Article
- Targeting hepatocyte carbohydrate transport to mimic fasting and calorie restriction.The FEBS journal · 2021Review
- Endometrial Glucose Transporters in Health and Disease.Frontiers in cell and developmental biology · 2021Review
- Alternative Splicing and Cleavage of GLUT8.Molecular and cellular biology · 2020Article
- Maternal diet modulates placental nutrient transporter gene expression in a mouse model of diabetic pregnancy.PloS one · 2019Article
- Multiple facilitated glucose transporters SLC2As are required for normal mouse preimplantation embryo development.American journal of translational research · 2019Article
- Expression of glucose transporters SLC2A1, SLC2A8, and SLC2A12 in different chicken muscles during ontogenesis.Journal of animal science · 2018Article
- Humanin (HN) and glucose transporter 8 (GLUT8) in pregnancies complicated by intrauterine growth restriction.PloS one · 2018Article
- SLC2A8 (GLUT8) is a mammalian trehalose transporter required for trehalose-induced autophagy.Scientific reports · 2016Article
- Obesity and PCOS: the effect of metabolic derangements on endometrial receptivity at the time of implantation.Reproductive sciences (Thousand Oaks, Calif.) · 2015Review
- Modeling the effect of cigarette smoke on hexose utilization in spermatocytes.Reproductive sciences (Thousand Oaks, Calif.) · 2015Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
SLC2A8, also known as GLUT8, is a facilitative glucose transporter expressed in the testis, brain, liver, heart, uterus, ovary, and fat. In this study we examined the effect of Slc2a8 deficiency on mouse gamete, preimplantation embryo, and implantation phenotype, as well as postnatal growth and physiology. For this model, the transcriptional start site and exons 1-4 were targeted and a lack of protein expression was confirmed by Western immunoblot. Oocytes obtained from Slc2a8(-/-) mice demonstrated abnormal metabolism and ATP production. In addition, deletion of Slc2a8 resulted in impaired decidualization, a critical step in the differentiation of endometrial stromal cells (ESCs), necessary for implantation. This indicates a role for SLC2A8 in decidualization, which is supported by Slc2a8 mRNA expression in both mouse and human ESCs, which increases dramatically in response to hormonal changes occurring during the process of implantation. Ovarian transplantation studies confirm that lack of SLC2A8 affects both the embryo and the implantation processes. This phenotype leads to decreased litter size, and smaller pups at weaning that continue to display an abnormally small growth phenotype into adulthood. The Slc2a8 null mice display decreased body fat by magnetic resonance imaging, and, interestingly, they are resistant to a diet high in fat and carbohydrates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.