ArticleBreast cancer research and treatment2012
Examination of ancestral informative markers and self-reported race with tumor characteristics of breast cancer among Black and White women.
Article in Breast cancer research and treatment, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Epidemiology, biology, and treatment of triple-negative breast cancer in women of African ancestry.The Lancet. Oncology · 2014Review
- Association of genetic ancestry with breast cancer in ethnically diverse women from Chicago.PloS one · 2014Article
- Cytokine genetic variations and fatigue among patients with breast cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2013Article
- Variation in tumor natural history contributes to racial disparities in breast cancer stage at diagnosis.Breast cancer research and treatment · 2013Article
- Evaluating genome-wide association study-identified breast cancer risk variants in African-American women.PloS one · 2013Article
Corrections and comments
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Authors and funding
19 authors.
Funding
Abstract
African American (AA) women have a higher mortality from breast cancer (BC) compared to European American (EA) women. This may be due to the higher proportion of AA women with tumors that are diagnosed at more advanced stages and are characterized as being estrogen receptor negative (ER-)/progesterone receptor negative (PR-). Our study sought to determine whether self-reported race and percent African ancestry were associated with BC tumor characteristics. In a multi-center, population-based case-control study of BC, we determined percent African ancestry using ancestry informative markers (AIM) among women self-reporting race as AA or Black. BC tumor characteristics were associated with self-reported race (including a 30 % reduction in ER+/PR+ tumors [95 % confidence interval [CI]: 0.6-0.9] and a 1.5-fold increased risk of high grade [95 % CI: 1.2-1.9] for AA women compared to EA women). AIMs among AA women were not associated with BC tumor characteristics (AA women with ≥95 % versus <80 % African ancestry, odds ratio [OR] = 1.0 for ER+/PR+ [95 % CI: 0.6-1.8] and OR = 0.9 for high-grade tumors [95 % CI: 0.6-1.4]). Similar findings were observed for BC stage. While BC subtypes were associated with self-reported race, BC subtypes were not associated with percent African ancestry. These study results suggest that subtle differences in percent African ancestry are less important than the overall presence of African ancestry in relation to BC tumor characteristics.
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