ArticleThe American journal of clinical nutrition2012
Cross-sectional study of conjugated linoleic acid in adipose tissue and risk of diabetes.
Article in The American journal of clinical nutrition, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Article
- Psychological determinants of the effectiveness of conjugated linoleic acid supplementation in overweight and obese women-a randomized controlled trial.Frontiers in nutrition · 2024Article
- Composition and contents of fatty acids and amino acids in the mycelia ofFood science & nutrition · 2023Article
- Enriched functional milk fat ameliorates glucose intolerance and triacylglycerol accumulation in skeletal muscle of rats fed high-fat diets.European journal of nutrition · 2023Article
- Milk Fatty Acid Profiles in Different Animal Species: Focus on the Potential Effect of Selected PUFAs on Metabolism and Brain Functions.Nutrients · 2021Review
- LysR Family Regulator LttR Controls Production of Conjugated Linoleic Acid in Lactobacillus plantarum by Directly Activating theApplied and environmental microbiology · 2021Article
- Alteration of fatty acid profile of milk in Holstein cows fedIranian journal of veterinary research · 2021Article
- Antiproliferation Activity and Mechanism of c9, t11, c15-CLNA and t9, t11, c15-CLNA fromMolecules (Basel, Switzerland) · 2020Article
- Double bond configuration of palmitoleate is critical for atheroprotection.Molecular metabolism · 2019Article
- Highly selective isomerization of cottonseed oil into conjugated linoleic acid catalyzed by multiwalled carbon nanotube supported ruthenium.RSC advances · 2019Article
- In vivo triglyceride composition of abdominal adipose tissue measured byJournal of magnetic resonance imaging : JMRI · 2017Article
- Serum pentadecanoic acid (15:0), a short-term marker of dairy food intake, is inversely associated with incident type 2 diabetes and its underlying disorders.The American journal of clinical nutrition · 2014Article
- Synthesis of conjugated linoleic acid by the linoleate isomerase complex in food-derived lactobacilli.Journal of applied microbiology · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
backgroundSome experimental studies on conjugated linoleic acid (CLA) and insulin regulation suggested that CLA could be associated with risk of diabetes, but epidemiologic studies are lacking.
objectiveThe aim of the study was to test whether the amount of CLA in adipose tissue is associated with risk of diabetes.
designA cross-sectional design was used to test the study hypothesis in 232 adults with diabetes and 1512 adults without diabetes who lived in Costa Rica. The cis-9, trans-11 and trans-10, cis-12 CLA isomers in adipose tissue and 48 other fatty acids were assessed by using gas chromatography. Prevalence ratios (PRs) and 95% CIs were estimated by using Poisson regression adjusted for potential confounders.
resultsThe mean (±SD) percentage of total fatty acids of CLA for the cis-9, trans-11 isomer in adipose tissue was 0.57 ± 0.18% in adults without diabetes and 0.53 ± 0.17% in adults with diabetes (P = 0.0078). The trans-10, cis-12 CLA isomer was not detected in adipose tissue. The cis-9, trans-11 CLA isomer was associated with a lower risk of diabetes. In comparison with the first quintile, the PR (95% CI) for the fifth quintile was 0.48 (0.31, 0.76) (P-trend = 0.0005) in the basic and 0.46 (0.29, 0.72) (P-trend = 0.0002) in the multivariable model. Additional adjustment for other fatty acids in adipose tissue including trans-9 16:1, which is a fatty acid that was previously associated with diabetes, did not modify the results.
conclusionThe observed inverse association between the cis-9, trans-11 CLA in adipose tissue and diabetes risk is consistent with the hypothesis that CLA may be involved in insulin regulation.
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