Evidence map›Paper›PMID 22648678›Full record

ArticleJournal of general internal medicine2012

Chapter 10: deciding whether to complement a systematic review of medical tests with decision modeling.

Thomas A Trikalinos, Shalini Kulasingam, William F Lawrence

Abstract read
In one paragraph

Article in Journal of general internal medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Generating and evaluating evidence of the clinical utility of molecular diagnostic tests in oncology.Genetics in medicine : official journal of the American College of Medical Genetics · 2016
    Article
  3. A flexible, multifaceted approach is needed in health technology assessment of PET.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2014
    Article
  4. Review
  5. Chapter 7: grading a body of evidence on diagnostic tests.Journal of general internal medicine · 2012
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Thomas A TrikalinosCenter for Evidence-based Medicine, and Department of Health Services Policy and Practice, Brown University, Providence, RI 02912, USA. thomas_trikalinos@brown.edu
Shalini Kulasingam
William F Lawrence

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Limited by what is reported in the literature, most systematic reviews of medical tests focus on "test accuracy" (or better, test performance), rather than on the impact of testing on patient outcomes. The link between testing, test results and patient outcomes is typically complex: even when testing has high accuracy, there is no guarantee that physicians will act according to test results, that patients will follow their orders, or that the intervention will yield a beneficial endpoint. Therefore, test performance is typically not sufficient for assessing the usefulness of medical tests. Modeling (in the form of decision or economic analysis) is a natural framework for linking test performance data to clinical outcomes. We propose that (some) modeling should be considered to facilitate the interpretation of summary test performance measures by connecting testing and patient outcomes. We discuss a simple algorithm for helping systematic reviewers think through this possibility, and illustrate it by means of an example.

Indexed as

Decision Support TechniquesDiagnostic Techniques and ProceduresGuidelines as TopicSystematic Reviews as TopicAlgorithmsEvidence-Based MedicineHumansSensitivity and Specificity

Identifiers

PMID22648678
PMCPMC3364358

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.