ReviewAnnals of biomedical engineering2012
Multiscale mechanics of articular cartilage: potentials and challenges of coupling musculoskeletal, joint, and microscale computational models.
Review in Annals of biomedical engineering, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 78 citations in OpenAlex.
- Diurnal variations in articular cartilage thickness and strain in the human knee.Journal of biomechanics · 2013Trial
- An exploratory patient-specific finite element study of temporomandibular joint stress distribution following mandibular setback surgery in two distinct clinical scenarios.BMC oral health · 2026Article
- A framework to assess mechano-tribological, structural and biochemical properties of articular cartilage.Frontiers in bioengineering and biotechnology · 2026Article
- Biomechanics of soft biological tissues and organs, mechanobiology, homeostasis and modelling.Journal of the Royal Society, Interface · 2025Review
- Contributions of cell behavior to geometric order in embryonic cartilage.PLoS computational biology · 2023Article
- Targeted mesenchymal stem cell therapy equipped with a cell-tissue nanomatchmaker attenuates osteoarthritis progression.Scientific reports · 2022Article
- A Multidisciplinary Journey towards Bone Tissue Engineering.Materials (Basel, Switzerland) · 2021Review
- Use of Computational Modeling to Study Joint Degeneration: A Review.Frontiers in bioengineering and biotechnology · 2020Review
- Proteoglycan degradation mimics static compression by altering the natural gradients in fibrillar organisation in cartilage.Acta biomaterialia · 2019Article
- Numerical Study on Electromechanics in Cartilage Tissue with Respect to Its Electrical Properties.Tissue engineering. Part B, Reviews · 2019Review
- Simulation of surface strain in tibiofemoral cartilage during walking for the prediction of collagen fiber orientation.Computer methods in biomechanics and biomedical engineering. Imaging & visualization · 2019Article
- Osteoarthritis as a disease of the cartilage pericellular matrix.Matrix biology : journal of the International Society for Matrix Biology · 2018Review
- Finite Element Formulation of Multiphasic Shell Elements for Cell Mechanics Analyses in FEBio.Journal of biomechanical engineering · 2018Article
- The effect of constitutive representations and structural constituents of ligaments on knee joint mechanics.Scientific reports · 2018Article
- The potential for intercellular mechanical interaction: simulations of single chondrocyte versus anatomically based distribution.Biomechanics and modeling in mechanobiology · 2018Article
- Article
- Systems approaches in osteoarthritis: Identifying routes to novel diagnostic and therapeutic strategies.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2017Article
- Advanced computational workflow for the multi-scale modeling of the bone metabolic processes.Medical & biological engineering & computing · 2017Review
- American Society of Biomechanics Clinical Biomechanics Award 2015: MRI assessments of cartilage mechanics, morphology and composition following reconstruction of the anterior cruciate ligament.Clinical biomechanics (Bristol, Avon) · 2016Article
- Modelling approaches for evaluating multiscale tendon mechanics.Interface focus · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Articular cartilage experiences significant mechanical loads during daily activities. Healthy cartilage provides the capacity for load bearing and regulates the mechanobiological processes for tissue development, maintenance, and repair. Experimental studies at multiple scales have provided a fundamental understanding of macroscopic mechanical function, evaluation of the micromechanical environment of chondrocytes, and the foundations for mechanobiological response. In addition, computational models of cartilage have offered a concise description of experimental data at many spatial levels under healthy and diseased conditions, and have served to generate hypotheses for the mechanical and biological function. Further, modeling and simulation provides a platform for predictive risk assessment, management of dysfunction, as well as a means to relate multiple spatial scales. Simulation-based investigation of cartilage comes with many challenges including both the computational burden and often insufficient availability of data for model development and validation. This review outlines recent modeling and simulation approaches to understand cartilage function from a mechanical systems perspective, and illustrates pathways to associate mechanics with biological function. Computational representations at single scales are provided from the body down to the microstructure, along with attempts to explore multiscale mechanisms of load sharing that dictate the mechanical environment of the cartilage and chondrocytes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.