Trial reportEuropean journal of applied physiology2013
Influence of heat stress and exercise intensity on vastus lateralis muscle and prefrontal cortex oxygenation.
Trial report in European journal of applied physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 48 citations in OpenAlex.
- Rehydration effect of qingshu buye decoction on exercise and high temperature-induced dehydration.Journal of the International Society of Sports Nutrition · 2024Trial
- The effects of carbonated cold water immersion of the arm during half-time on intermittent exercise performance in the heat.European journal of applied physiology · 2026Article
- Influence of Foot and Legwear Color on Lower-Limb Temperature in Baseball Players Under Heat Stress.Sports (Basel, Switzerland) · 2025Article
- Time-continuous analysis of muscle and cerebral oxygenation during repeated treadmill sprints under heat stress: a statistical parametric mapping study.European journal of applied physiology · 2025Article
- Differential impact of heat and hypoxia on dynamic oxygen uptake and deoxyhemoglobin parameters during incremental exhaustive exercise.Frontiers in physiology · 2023Article
- A Combined Hot and Hypoxic Environment during Maximal Cycling Sprints Reduced Muscle Oxygen Saturation: A Pilot Study.Journal of sports science & medicine · 2021Article
- Effects of combined hot and hypoxic conditions on muscle blood flow and muscle oxygenation during repeated cycling sprints.European journal of applied physiology · 2021Article
- Monitoring adaptation of skin tissue oxygenation during cycling ergometer exercise by frequency-domain diffuse optical spectroscopy.Biomedical optics express · 2021Article
- Effects of Acute Exposure to Thermal Stress on Cardiorespiratory Function, Skeletal Muscle Oxygenation, and Exercise Performance in Healthy Males.International journal of environmental research and public health · 2021Article
- Effect of regular precooling on adaptation to training in the heat.European journal of applied physiology · 2020Article
- Endocrine and Metabolic Responses to Endurance Exercise Under Hot and Hypoxic Conditions.Frontiers in physiology · 2020Article
- Integrating Heat Training in the Rehabilitation Toolbox for the Injured Athlete.Frontiers in physiology · 2019Article
- Effect of ice slushy ingestion and cold water immersion on thermoregulatory behavior.PloS one · 2019Article
- Skin Temperature Measurement Using Contact Thermometry: A Systematic Review of Setup Variables and Their Effects on Measured Values.Frontiers in physiology · 2018Review
- The influence of a mild thermal challenge and severe hypoxia on exercise performance and serum BDNF.European journal of applied physiology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study examined whether a rise in thermal and cardiovascular strain during exercise to exhaustion in the heat at different intensities is associated with compromised muscle and cerebral oxygenation. Using near-infrared spectroscopy, oxygenation changes in the vastus lateralis and prefrontal cortex of ten subjects cycling to exhaustion in 40 °C conditions at 60 % (H60%) and 75 % (H75%) maximal oxygen uptake (VO₂(max)) and for 60 min in 18 °C conditions at 60 % VO₂(max) (C60%) were examined. Thermoregulatory and cardiovascular responses were also monitored. Rectal temperature reached 38.1 °C in the C60% trial, 39.7 °C (~60 min) and 39.0 °C (~27 min) in the H60% and H75% trials, respectively (P < 0.001). The core-to-skin temperature gradient was similarly narrow (~0.9 °C) at exhaustion in the heat, occurring >97 % of maximum heart rate and accompanied by significant declines in stroke volume, cardiac output and mean arterial pressure (P < 0.01). Vastus lateralis oxygen saturation (SmO(2)) declined at the onset of exercise in all conditions, remaining similarly depressed at exhaustion in the heat. Prefrontal cortex oxygen saturation (ScO(2)) was ~10 % lower at exhaustion in the H60% and H75% trials compared with C60% (P < 0.01), which remained above baseline from 15 min onward. These findings indicate that changes in SmO(2) and ScO(2) are associated with the development of thermal and cardiovascular strain during exercise to exhaustion in the heat, which is accelerated by exercise intensity. In locomotor muscles, a potential reduction in oxygen delivery may develop, whereas in the brain, the progressive reduction in ScO(2) may induce mental fatigue.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.