ReviewJournal of molecular medicine (Berlin, Germany)2012
Mesenchymal stromal cells (MSCs): science and f(r)iction.
Review in Journal of molecular medicine (Berlin, Germany), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 58 citations in OpenAlex.
- Inhibition of Small Extracellular Vesicles by GW4869 Does not Disrupt the Paracrine Regulation of Adipose-Derived Mesenchymal Stem Cells Over Keloid Fibroblasts.Aesthetic plastic surgery · 2025Article
- Assessment of Short-Term Effects of Cell Transplantation in Cirrhosis DUE to HCV.Asian Pacific journal of cancer prevention : APJCP · 2024Article
- New treatment methods for myocardial infarction.Frontiers in cardiovascular medicine · 2023Review
- Closer to Nature: The Role of MSCs in Recreating the Microenvironment of the Hematopoietic Stem Cell Niche in vitro.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2022Review
- Allogeneic adipose tissue-derived stem cells ELIXCYTEJournal of cellular and molecular medicine · 2022Article
- Autophagy, Mesenchymal Stem Cell Differentiation, and Secretion.Biomedicines · 2021Review
- 3D-Bioprinting Strategies Based on In Situ Bone-Healing Mechanism for Vascularized Bone Tissue Engineering.Micromachines · 2021Review
- Efficient isolation and proliferation of human adipose-derived mesenchymal stromal cells in xeno-free conditions.Molecular biology reports · 2020Article
- Aerosolised Mesenchymal Stem Cells Expressing Angiopoietin-1 Enhances Airway Repair.Stem cell reviews and reports · 2019Article
- Novel preconditioning strategies for enhancing the migratory ability of mesenchymal stem cells in acute kidney injury.Stem cell research & therapy · 2018Review
- Clinical Translation of Mesenchymal Stromal Cell Therapies in Nephrology.Journal of the American Society of Nephrology : JASN · 2018Review
- Stem/Stromal Cells for Treatment of Kidney Injuries With Focus on Preclinical Models.Frontiers in medicine · 2018Review
- p53-Dependent Senescence in Mesenchymal Stem Cells under Chronic Normoxia Is Potentiated by Low-Dose γ-Irradiation.Stem cells international · 2016Article
- Using Stem Cells to Grow Artificial Tissue for Peripheral Nerve Repair.Stem cells international · 2016Review
- Using mesenchymal stem cells as a therapy for bone regeneration and repairing.Biological research · 2015Review
- Controversial Role of Toll-like Receptor 4 in Adult Stem Cells.Stem cell reviews and reports · 2015Review
- In Vitro Evaluation of Scaffolds for the Delivery of Mesenchymal Stem Cells to Wounds.BioMed research international · 2015Article
- Umbilical cord blood transplantation supplemented with the infusion of mesenchymal stem cell for an adolescent patient with severe aplastic anemia: a case report and review of literature.Patient preference and adherence · 2015Article
- Transcriptomic portrait of human Mesenchymal Stromal/Stem Cells isolated from bone marrow and placenta.BMC genomics · 2014Article
- Cell-based approaches to the engineering of vascularized bone tissue.Cytotherapy · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 8 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Due to their multi-lineage differentiation capacity, support of haematopoiesis, immunomodulation and secretion of proregenerative factors, mesenchymal stem/stromal cells (MSCs) are in the focus of intense research since decades. The literature is replete with reports on their potential in preclinical model systems. However, the heterogeneity of the primary cell population as starting material and the diverse protocols for isolation and cultivation are hampering progress in their clinical application. Consensus on common standards and harmonised isolation and characterisation protocols are important to ensure safety and efficacy. This review focuses on the recent scientific evidence of clinically relevant properties and on the speculative cardiomyogenic and hepatic differentiation potential of MSCs. Special emphasis is put on the importance of standardisation and harmonisation in clinical-scale manufacturing.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.