ArticleMovement disorders : official journal of the Movement Disorder Society2012
Short latency activation of cortex during clinically effective subthalamic deep brain stimulation for Parkinson's disease.
Article in Movement disorders : official journal of the Movement Disorder Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
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81 citing papers in PubMed, 135 citations in OpenAlex.
- Clinical utility of evoked potentials for programming subthalamic deep brain stimulation in Parkinsons disease.NPJ Parkinson's disease · 2026Review
- Subthalamic nucleus in patients with Parkinson's disease encodes changes and magnitude of applied force.NPJ Parkinson's disease · 2026Article
- Hyperdirect projections from the supplementary motor area mediate subthalamic stimulation effects on movement initiation and inhibition in Parkinson's disease.Brain communications · 2026Article
- Electrophysiological Biomarkers Reflect Target Engagement and Response Using Deep Brain Stimulation for Obsessive-Compulsive Disorder.Biological psychiatry global open science · 2026Article
- Paired Deep Brain Stimuli Elicit Short-Term Facilitation in Globus Pallidus Interna and Subthalamic Nucleus.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Gamma entrainment induced by deep brain stimulation as a biomarker for motor improvement with neuromodulation.Nature communications · 2025Article
- Neural pathway activation in the subthalamic region depends on stimulation polarity.Brain communications · 2025Article
- A framework for translational therapy development in deep brain stimulation.NPJ Parkinson's disease · 2024Review
- Does Vestibular Motion Perception Correlate with Axonal Pathways Stimulated by Subthalamic Deep Brain Stimulation in Parkinson's Disease?Cerebellum (London, England) · 2024Article
- Modulation of DBS-induced cortical responses and movement by the directionality and magnitude of current administered.NPJ Parkinson's disease · 2024Article
- Coupled Activation of the Hyperdirect and Cerebellothalamic Pathways with Zona Incerta Deep Brain Stimulation.Movement disorders : official journal of the Movement Disorder Society · 2024Article
- The Therapeutic Frequency Profile of Subthalamic Nucleus Deep Brain Stimulation in Rats Is Shaped by Antidromic Spike Failure.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- DBS-evoked cortical responses index optimal contact orientations and motor outcomes in Parkinson's disease.NPJ Parkinson's disease · 2023Article
- Evolving characterization of the human hyperdirect pathway.Brain structure & function · 2023Review
- Combining Transcranial Magnetic Stimulation and Deep Brain Stimulation: Current Knowledge, Relevance and Future Perspectives.Brain sciences · 2023Review
- Myogenic and cortical evoked potentials vary as a function of stimulus pulse geometry delivered in the subthalamic nucleus of Parkinson's disease patients.Frontiers in neurology · 2023Article
- Low-frequency deep brain stimulation reveals resonant beta-band evoked oscillations in the pallidum of Parkinson's Disease patients.Frontiers in human neuroscience · 2023Article
- Anatomical substrates and connectivity for bradykinesia motor features in Parkinson's disease after subthalamic nucleus deep brain stimulation.Brain communications · 2023Article
- Stability and Effect of Parkinsonian State on Deep Brain Stimulation Cortical Evoked Potentials.Neuromodulation : journal of the International Neuromodulation Society · 2022Article
- Modulation of sensory cortical activity by deep brain stimulation in advanced Parkinson's disease.The European journal of neuroscience · 2022Article
21 more citing papers are in PubMed but not listed here.
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10 authors at 1 institution in 1 country.
Funding
Abstract
Subthalamic deep brain stimulation (DBS) is superior to medical therapy for the motor symptoms of advanced Parkinson's disease (PD), and additional evidence suggests that it improves refractory symptoms of essential tremor, primary generalized dystonia, and obsessive-compulsive disorder. Despite this, its therapeutic mechanism is unknown. We hypothesized that subthalamic stimulation activates the cerebral cortex at short latencies after stimulus onset during clinically effective stimulation for PD. In 5 subjects (six hemispheres), EEG measured the response of cortex to subthalamic stimulation across a range of stimulation voltages and frequencies. Novel analytical techniques reversed the anode and cathode electrode contacts and summed the resulting pair of event-related potentials to suppress the stimulation artifact. We found that subthalamic brain stimulation at 20 Hz activates the somatosensory cortex at discrete latencies (mean latencies: 1.0 ± 0.4, 5.7 ± 1.1, and 22.2 ± 1.8 ms, denoted as R1, R2, and R3, respectively). The amplitude of the short latency peak (R1) during clinically effective high-frequency stimulation is nonlinearly dependent on stimulation voltage (P < 0.001; repeated-measures analysis of variance), and its latency is less variable than that of R3 (1.02 versus 19.46 ms; P < 0.001, Levene's test). We conclude that clinically effective subthalamic brain stimulation in humans with PD activates the cerebral cortex at 1 ms after stimulus onset, most likely by antidromic activation. These findings suggest that alteration of the precise timing of action potentials in cortical neurons with axonal projections to the subthalamic region may be an important component of the therapeutic mechanism of subthalamic brain stimulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.