ArticleClinical reviews in allergy & immunology2012
The multiple autoimmune syndromes. A clue for the autoimmune tautology.
Article in Clinical reviews in allergy & immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- How do autoimmune diseases cluster in families? A systematic review and meta-analysis.BMC medicine · 2013Pooled it
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- Polyautoimmunity in systemic lupus erythematosus patients: New insights from a cross-sectional study.Journal of translational autoimmunity · 2023Article
- A suspected case of a multiple autoimmune syndrome in a poodle dog.Veterinary medicine and science · 2022Article
- Multiple autoimmune syndrome complicating the management of diabetic retinopathy.American journal of ophthalmology case reports · 2020Article
- Hydroxychloroquine is associated with a lower risk of polyautoimmunity: data from the RELESSER Registry.Rheumatology (Oxford, England) · 2020Article
- Promoter methylation and expression of intercellular adhesion molecule 1 gene in blood of autoimmune thyroiditis patients.Molecular biology reports · 2019Article
- Risk of Developing Additional Immune-Mediated Manifestations: A Retrospective Matched Cohort Study.Advances in therapy · 2019Article
- Sjögren's Syndrome and Autoimmune Thyroid Disease: Two Sides of the Same Coin.Clinical reviews in allergy & immunology · 2019Article
- Psoriasis, Vitiligo and Crohn's Disease Co-Existing in a Single Patient: A Variant Type of Multiple Autoimmune Syndrome?Annals of dermatology · 2017Article
- Cytokine and autoantibody clusters interaction in systemic lupus erythematosus.Journal of translational medicine · 2017Article
- A Review of Autoimmune Disease Hypotheses with Introduction of the "Nucleolus" Hypothesis.Clinical reviews in allergy & immunology · 2017Review
- HLA-DRB1 the notorious gene in the mosaic of autoimmunity.Immunologic research · 2017Article
- Recent advances in understanding autoimmune thyroid disease: the tallest tree in the forest of polyautoimmunity.F1000Research · 2017Review
- Autoimmune vitiligo in rheumatic disease in the mestizo Mexican population.Biomedical reports · 2016Article
- Novel and rare functional genomic variants in multiple autoimmune syndrome and Sjögren's syndrome.Journal of translational medicine · 2015Article
- Familial Aggregation and Segregation Analysis in Families Presenting Autoimmunity, Polyautoimmunity, and Multiple Autoimmune Syndrome.Journal of immunology research · 2015Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The multiple autoimmune syndromes (MAS) consist on the presence of three or more well-defined autoimmune diseases (ADs) in a single patient. The aim of this study was to analyze the clinical and genetic characteristics of a large series of patients with MAS. A cluster analysis and familial aggregation analysis of ADs was performed in 84 patients. A genome-wide microsatellite screen was performed in MAS families, and associated loci were investigated through the pedigree disequilibrium test. Systemic lupus erythematosus (SLE), autoimmune thyroid disease (AITD), and Sjögren's syndrome together were the most frequent ADs encountered. Three main clusters were established. Aggregation for type 1 diabetes, AITD, SLE, and all ADs as a trait was found. Eight loci associated with MAS were observed harboring autoimmunity genes. The MAS represent the best example of polyautoimmunity as well as the effect of a single genotype on diverse phenotypes. Its study provides important clues to elucidate the common mechanisms of ADs (i.e., autoimmune tautology).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.