ArticleJournal of assisted reproduction and genetics2012
Clinical data for 185 infertile Iranian men with Y-chromosome microdeletion.
Article in Journal of assisted reproduction and genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 50 citations in OpenAlex.
- WT1 pathogenic variant in azoospermic infertile men with an isolated undescended testis.Clinical and experimental reproductive medicine · 2025Article
- An analysis of Y-chromosome microdeletion in infertile Korean men with severe oligozoospermia or azoospermia.Investigative and clinical urology · 2024Article
- High incidence of AZF duplications in clan-structured Iranian populations detected through Y chromosome sequencing read depth analysis.Scientific reports · 2023Article
- Bridging the Gap between AZF Microdeletions and Karyotype: Twelve Years' Experience of an Infertility Center.The world journal of men's health · 2023Article
- Prevalence of Y chromosome microdeletions among infertile Mongolian men.Clinical and experimental reproductive medicine · 2022Article
- The genetic causes of male infertility: a Middle East and North Africa perspective.F1000Research · 2022Review
- Repetitive DNA Sequences in the Human Y Chromosome and Male Infertility.Frontiers in cell and developmental biology · 2022Review
- The frequencies of Y chromosome microdeletions in infertile males.Turkish journal of urology · 2018Article
- Detection of Y Chromosome Microdeletions and Hormonal Profile Analysis of Infertile Men undergoing Assisted Reproductive Technologies.International journal of fertility & sterility · 2018Article
- Basic and clinical genetic studies on male infertility in Iran during 2000-2016: A review.International journal of reproductive biomedicine · 2018Review
- Multiplex-Polymerase Chain Reaction for Detecting Microdeletions in The Azoospermia Factor Region of Y Chromosome in Iranian Couples with Non-Obstructive Infertility and Recurrent Pregnancy Loss.International journal of fertility & sterility · 2018Article
- Association of rs1057035polymorphism in microRNA biogenesis pathway gene (DICER1) with azoospermia among Iranian population.Genes & genomics · 2018Article
- Y chromosome azoospermia factor region microdeletions and transmission characteristics in azoospermic and severe oligozoospermic patients.International journal of clinical and experimental medicine · 2015Review
- A Rare De novo Complex Chromosomal Rearrangement (CCR) Involving Four Chromosomes in An Oligo-asthenosperm Infertile Man.Cell journal · 2014Article
- Human spermatozoa: revelations on the road to conception.F1000prime reports · 2013Review
- Ubiquitin-specific protease (USP26) gene alterations associated with male infertility and recurrent pregnancy loss (RPL) in Iranian infertile patients.Journal of assisted reproduction and genetics · 2013Article
- Association between Y-chromosome AZFc region micro-deletions with recurrent miscarriage.Iranian journal of reproductive medicine · 2013Article
- Y-chromosome microdeletions in nonobstructive azoospermia and severe oligozoospermia.Asian journal of andrologyArticle
- Frequency of Y Chromosome Microdeletions Among Iranian Infertile Men with Azoospermia and Severe Oligozoospermia: A Meta-analysis.Journal of reproduction & infertilityArticle
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Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledDetection of Y-chromosome microdeletion is useful to obtain reliable genetic information for assisted reproductive techniques, thus avoiding unnecessary treatment and vertical transmission of genetic defects. PURPOSES: This research was conducted over a six-year period to analyze clinical data, somatic cytogenetic abnormalities, and types of microdeletions in men with fertility disorders in Iran. METHODS AND PATIENTS: A total of 3654 infertile men were included in this study. Semen samples were analyzed according to standard methods. Conventional chromosomal karyotyping was used to analyze chromosome abnormalities. Polymerase chain reaction (PCR) amplification using nine specific sequence-tagged sites (STS) was used to detect AZF microdeletions.
resultsOut of the 3654 patients who were analyzed, AZF region microdeletions were detected in 185 cases (5.06 %). Karyotype analysis was available for 157 men and among them abnormal karyotypes were found in 51 cases (32.48 %). One hundred and forty-seven cases with Yq microdeletions suffered from azoospermia and 38 from severe oligozoospermia. Our data show that the most frequent microdeletions were in the AZFc region, followed by the AZFb + c + d, AZFb + c, AZFb, AZFa, and AZF a + c regions.
conclusionThe study has confirmed that the detection of microdeletions in the AZF region is significant from a diagnostic viewpoint. It is also useful to obtain reliable genetic information from infertile men to determine the etiology of the deletions, and to avoid unnecessary treatments and vertical transmission of genetic defects.
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