ArticleJournal of human hypertension2013
Genetically elevated levels of circulating triglycerides and brachial-ankle pulse wave velocity in a Chinese population.
Article in Journal of human hypertension, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genetic polymorphism of apolipoprotein A5 gene and susceptibility to type 2 diabetes mellitus: a meta-analysis of 15,137 subjects.PloS one · 2014Pooled it
- Comparison of arterial stiffness indices measured by pulse wave velocity and pulse wave analysis for predicting cardiovascular and all-cause mortality in a Chinese population.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Determinants of Brachial-Ankle Pulse Wave Velocity and Vascular Aging in Healthy Older Subjects.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Subacute oral toxicity of ayurvedic anti-diabetic preparationToxicology reports · 2020Article
- Age-differential association between serum uric acid and incident hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2019Article
- Interaction between body mass index and serum uric acid in relation to blood pressure in community-dwelling Japanese men.Clinical hypertension · 2018Article
- Association and Interaction Analysis of Body Mass Index and Triglycerides Level with Blood Pressure in Elderly Individuals in China.BioMed research international · 2018Article
- Factors associated with high brachial-ankle pulse wave velocity in non-hypertensive and appropriately treated hypertensive patients with atherosclerotic risk factors.Vascular health and risk management · 2017Article
- Prevalence and associated factors of knee osteoarthritis in a rural Chinese adult population: an epidemiological survey.BMC public health · 2016Article
- Relationship between brachial-ankle pulse wave velocity and metabolic syndrome components in a Chinese population.Journal of biomedical research · 2014Article
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Elevated levels of circulating triglycerides and increased arterial stiffness are associated with cardiovascular disease. Numerous studies have reported an association between levels of circulating triglycerides and arterial stiffness. We used Mendelian randomization to test whether this association is causal. We investigated the association between circulating triglyceride levels, the apolipoprotein A-V (ApoA5) -1131T>C single nucleotide polymorphism and brachial-ankle pulse wave velocity (baPWV) by examining data from 4421 subjects aged 18-74 years who were recruited from the Chinese population. baPWV was significantly associated with the levels of circulating triglycerides after adjusting for age, sex, body mass index (BMI), systolic blood pressure, heart rate, waist-to-hip ratio, antihypertensive treatment and diabetes mellitus status. The -1131C allele was associated with a 5% (95% confidence interval 3-8%) increase in circulating triglycerides (adjusted for age, sex, BMI, waist-to-hip ratio, diabetes mellitus and antihypertensive treatment). Instrumental variable analysis showed that genetically elevated levels of circulating triglycerides were not associated with increased baPWV. These results do not support the hypothesis that levels of circulating triglycerides have a causal role in the development of arterial stiffness.
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Registered trials
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