ArticleMedical science monitor : international medical journal of experimental and clinical research2012
Genetic variations in E-selectin and ICAM-1: relation to atherosclerosis.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 6 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 6 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Association between K469E polymorphism of ICAM-1 gene and susceptibility of ischemic stroke: An updated meta-analysis.Molecular genetics & genomic medicine · 2019Pooled it
- Associations of intercellular adhesion molecule-1 rs5498 polymorphism with ischemic stroke: A meta-analysis.Molecular genetics & genomic medicine · 2019Pooled it
- Pooled it
- Correlations of SELE and SELP genetic polymorphisms with myocardial infarction risk: a meta-analysis and meta-regression.Molecular biology reports · 2014Pooled it
- SELP genetic polymorphisms may contribute to the pathogenesis of coronary heart disease and myocardial infarction: a meta-analysis.Molecular biology reports · 2014Pooled it
- Association of A561C and G98T polymorphisms in E-selectin gene with coronary artery disease: a meta-analysis.PloS one · 2013Pooled it
- Hepatocyte growth factor enhances the ability of dental pulp stem cells to ameliorate atherosclerosis in apolipoprotein E-knockout mice.World journal of stem cells · 2024Article
- Causal relationship between inflammatory factors and cerebral small vessel disease: Univariate, multivariate, and summary-data-based mendelian randomization analysis.Brain and behavior · 2024Article
- Review
- Safety assessment of drug combinations used in COVID-19 treatment: in silico toxicogenomic data-mining approach.Toxicology and applied pharmacology · 2020Article
- Polymorphism rs5498 of the ICAM-1 gene affects the progression of carotid atherosclerosis in patients with type 2 diabetes mellitus.Lipids in health and disease · 2016Article
- Influence of phenotype conversion of epicardial adipocytes on the coronary atherosclerosis and its potential molecular mechanism.American journal of translational research · 2015Article
- Adiponectin abates atherosclerosis by reducing oxidative stress.Medical science monitor : international medical journal of experimental and clinical research · 2014Article
- Assessment of the E-selectin rs5361 (561A>C) polymorphism and soluble protein concentration in acute coronary syndrome: association with circulating levels.Mediators of inflammation · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aimed to investigate the association of both intercellular adhesion molecule-1 (ICAM-1) and endothelial cell adhesion molecule (E-selectin) polymorphisms using PCR technique and their role in the pathogenesis of atherosclerosis. MATERIAL/
methodsThe study enrolled 285 individuals, classified into 4 groups: 63 cerebrovascular atherosclerotic patients, 75 cardiovascular patients, 72 peripheral atherosclerotic patients and 75 normal healthy individuals.
resultsThe frequency of the mutant AC genotype of E-selectin in peripheral, cerebral and cardiovascular atherosclerotic patients was significantly higher than in control subjects (29.17%, 28.53% and 28% vs. 8%, respectively). However, no significant difference was observed in the frequency of mutant CC allele between all atherosclerotic patients and control groups. The frequency of the mutant EE homozygotes of ICAM-1 in peripheral, cerebral and cardiovascular atherosclerotic patients was significantly higher compared to controls (45.8%, 42.9% and 36% vs. 12%, respectively). The frequency of EK of ICAM-1 showed no significant difference between atherosclerotic patients and the control group. The frequency of the mutant E allele of ICAM-1 was significantly higher in peripheral, cerebral and cardiovascular patients compared to controls (58.3%, 54.8% and 54% vs. 26%, respectively).
conclusionsSer 128Arg of E-selectin and the K469E of ICAM-1 polymorphisms may be involved in predisposition to atherosclerosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.