ArticleMedical science monitor : international medical journal of experimental and clinical research2012
Induction of osteoporosis with its influence on osteoporotic determinants and their interrelationships in rats by DEXA.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Single and combined use of human parathyroid hormone (PTH) (1-34) on areal bone mineral density (aBMD) in postmenopausal women with osteoporosis: evidence based on 9 RCTs.Medical science monitor : international medical journal of experimental and clinical research · 2014Pooled it
- Bone loss and increased bone marrow adiposity in ovary-intact and ovariectomized rats with chronic obstructive pulmonary disease.Journal of endocrinological investigation · 2025Article
- Effects of Ovariectomy and Low-Calcium Diet on Six Different Sites of the Rat Skeleton.Biomimetics (Basel, Switzerland) · 2025Article
- Mesoporous Bioactive Glass-Incorporated Injectable Strontium-Containing Calcium Phosphate Cement Enhanced Osteoconductivity in a Critical-Sized Metaphyseal Defect in Osteoporotic Rats.Bioengineering (Basel, Switzerland) · 2023Article
- Development of a Metaphyseal Non-Union Model in the Osteoporotic Rat Femur.Bioengineering (Basel, Switzerland) · 2023Article
- Large Animal Model of Osteoporotic Defect Healing: An Alternative to Metaphyseal Defect Model.Life (Basel, Switzerland) · 2021Article
- Accuracy, agreement, and reliability of DECT-derived vBMD measurements: an initial ex vivo study.European radiology · 2021Article
- WNT3A accelerates delayed alveolar bone repair in ovariectomized mice.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019Article
- Investigation of strontium transport and strontium quantification in cortical rat bone by time-of-flight secondary ion mass spectrometry.Journal of the Royal Society, Interface · 2019Article
- Effects of a Pasty Bone Cement Containing Brain-Derived Neurotrophic Factor-Functionalized Mesoporous Bioactive Glass Particles on Metaphyseal Healing in a New Murine Osteoporotic Fracture Model.International journal of molecular sciences · 2018Article
- Investigation of candidate genes and mechanisms underlying postmenopausal osteoporosis using bioinformatics analysis.Molecular medicine reports · 2018Article
- miR-142-5p in Bone Marrow-Derived Mesenchymal Stem Cells Promotes Osteoporosis Involving Targeting Adhesion Molecule VCAM-1 and Inhibiting Cell Migration.BioMed research international · 2018Article
- Bergapten promotes bone marrow stromal cell differentiation into osteoblasts in vitro and in vivo.Molecular and cellular biochemistry · 2015Article
- MiR-133 is Involved in Estrogen Deficiency-Induced Osteoporosis through Modulating Osteogenic Differentiation of Mesenchymal Stem Cells.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- Effects of P-15 Peptide Coated Hydroxyapatite on Tibial Defect Repair In Vivo in Normal and Osteoporotic Rats.BioMed research international · 2015Article
- Application of F-18-sodium fluoride (NaF) dynamic PET-CT (dPET-CT) for defect healing: a comparison of biomaterials in an experimental osteoporotic rat model.Medical science monitor : international medical journal of experimental and clinical research · 2014Article
- Expression of muscarinic acetylcholine receptors M3 and M5 in osteoporosis.Medical science monitor : international medical journal of experimental and clinical research · 2014Article
- Change of mechanical vertebrae properties due to progressive osteoporosis: combined biomechanical and finite-element analysis within a rat model.Medical & biological engineering & computing · 2014Article
- Implications of combined ovariectomy and glucocorticoid (dexamethasone) treatment on mineral, microarchitectural, biomechanical and matrix properties of rat bone.International journal of experimental pathology · 2013Article
- Applicability of ToF-SIMS for monitoring compositional changes in bone in a long-term animal model.Journal of the Royal Society, Interface · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAs women are the population most affected by multifactorial osteoporosis, research is focused on unraveling the underlying mechanism of osteoporosis induction in rats by combining ovariectomy (OVX) either with calcium, phosphorus, vitamin C and vitamin D2/D3 deficiency, or by administration of glucocorticoid (dexamethasone). MATERIAL/
methodsDifferent skeletal sites of sham, OVX-Diet and OVX-Steroid rats were analyzed by Dual Energy X-ray Absorptiometry (DEXA) at varied time points of 0, 4 and 12 weeks to determine and compare the osteoporotic factors such as bone mineral density (BMD), bone mineral content (BMC), area, body weight and percent fat among different groups and time points. Comparative analysis and interrelationships among osteoporotic determinants by regression analysis were also determined.
resultsT scores were below-2.5 in OVX-Diet rats at 4 and 12 weeks post-OVX. OVX-diet rats revealed pronounced osteoporotic status with reduced BMD and BMC than the steroid counterparts, with the spine and pelvis as the most affected skeletal sites. Increase in percent fat was observed irrespective of the osteoporosis inducers applied. Comparative analysis and interrelationships between osteoporotic determinants that are rarely studied in animals indicate the necessity to analyze BMC and area along with BMD in obtaining meaningful information leading to proper prediction of probability of osteoporotic fractures.
conclusionsEnhanced osteoporotic effect observed in OVX-Diet rats indicates that estrogen dysregulation combined with diet treatment induces and enhances osteoporosis with time when compared to the steroid group. Comparative and regression analysis indicates the need to determine BMC along with BMD and area in osteoporotic determination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.