ArticleSurgical endoscopy2012
Normokinetic biliary dyskinesia: a novel diagnosis.
Article in Surgical endoscopy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 31 citations in OpenAlex.
- Pediatric gallbladder dyskinesia managed with laparoscopic cholecystectomy: A case report and literature review.International journal of surgery case reports · 2025Article
- Article
- The Chronic Acalculous Symptomatic Hyperkinetic (CASPER) Gallbladder or "JSM gastroenterology and hepatology · 2023Article
- Biliary hyperkinesia: an indication for cholecystectomy?Surgical endoscopy · 2021Article
- Biliary hyperkinesia in adolescents-it isn't all hype!Translational gastroenterology and hepatology · 2021Article
- Role of Cholecystectomy in Symptomatic Hyperkinetic Gallbladder Patients.Case reports in surgery · 2021Article
- Is hyperkinetic gallbladder an indication for cholecystectomy?Surgical endoscopy · 2019Article
- Biliary hyperkinesia, a new diagnosis or misunderstood pathophysiology of dyskinesia: A case report.International journal of surgery case reports · 2019Article
- Biliary dyskinesia and symptomatic gallstone disease in children: two sides of the same coin?Digestive diseases and sciences · 2014Article
- Multi-institutional analysis of long-term symptom resolution after cholecystectomy for biliary dyskinesia in children.Pediatric surgery international · 2013Article
- Is abnormal gallbladder ejection fraction hokum? Retrospective chart review of gallbladder ejection fraction and subsequent postoperative symptom relief, surgical pathology, and current literature review.World journal of nuclear medicineArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBiliary dyskinesia diagnosed with CCK-HIDA scan and ejection fraction less than 35 % has been successfully treated by laparoscopic cholecystectomy. However, a population of patients with symptomatic biliary pain and a normal CCK-HIDA scan never receive a diagnosis, and thus no definitive treatment. Some of these patients report a reproducible pain during their CCK-HIDA scan. It is hypothesized that these patients have a novel diagnosis, normokinetic biliary dyskinesia, and may have resolution of pain when treated with cholecystectomy.
methodsA retrospective chart review was completed looking for patients with biliary pain in accordance with the ROME III criteria. Additional inclusion criteria were (1) greater than age 18 years, (2) reproducible biliary symptoms during the CCK-HIDA scan, and (3) an ejection fraction greater than 35 %. Treatment modality was laparoscopic cholecystectomy. Descriptive statistics were preformed, and data were reported as mean ± standard deviation and range.
resultsNineteen patients met the inclusion criteria for this study from August 2008 to July 2011. There were 15 women and 4 men with a mean age of 48.4 ± 13.0 years. The mean ejection fraction was 75.1 ± 19.4 %. The average duration of preoperative symptoms was 6.8 ± 5.9 months and postoperative follow-up was 21.8 ± 10.6 months. Seventeen patients had complete resolution of symptoms, one had partial resolution, and one had no change. There was a complete resolution rate of 89.5 % and an improvement rate of 94.7 %.
conclusionsWe suggest that patients who present with biliary pain, a normal CCK-HIDA scan with an ejection fraction greater than 35 %, and with reproducible symptoms on infusion of CCK could have a novel diagnosis: normokinetic biliary dyskinesia. Currently, these patients are excluded from the diagnosis of biliary dyskinesia and thus treatment. We hypothesize a potential new diagnosis, suggest cholecystectomy as treatment, and recommend a prospective study design for further evaluation.
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