ArticleSurgical endoscopy2012
Differences in biomechanical stability using various fibrin glue compositions for mesh fixation in endoscopic inguinal hernia repair.
Article in Surgical endoscopy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- What do we know about titanized polypropylene meshes? An evidence-based review of the literature.Hernia : the journal of hernias and abdominal wall surgery · 2014Pooled it
- Multicentric pragmatic randomized controlled trial of mesh fixation system in primary and recurrent ventral hernia repair.Updates in surgery · 2026Article
- Assessment of short-term outcome with TiOBMC surgery · 2019Article
- Surface modification of polypropylene surgical meshes for improving adhesion with poloxamine hydrogel adhesive.Journal of biomedical materials research. Part B, Applied biomaterials · 2019Article
- Biomechanical evaluation of fixation properties of fibrin glue for ventral incisional hernia repair.Hernia : the journal of hernias and abdominal wall surgery · 2015Article
- Biomechanical evaluation of three fixation modalities for preperitoneal inguinal hernia repair: a 24-hour postoperative study in pigs.Medical devices (Auckland, N.Z.) · 2014Article
- Fibrin Sealant: The Only Approved Hemostat, Sealant, and Adhesive-a Laboratory and Clinical Perspective.ISRN surgery · 2014Review
- Biomechanical properties of (semi-) synthetic glues for mesh fixation in endoscopic inguinal hernia repair.Hernia : the journal of hernias and abdominal wall surgery · 2013Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn hernia surgery, mesh fixation with fibrin glue instead of tacks and sutures can demonstrably reduce postoperative morbidity without increasing recurrence rates. In some cases there are significant differences in the biomechanical properties, depending on the functional structure of the meshes. Furthermore, there are various fibrin glue products on the market and these are used for mesh fixation. This study compared the fixation strength of fibrin glues in combination with various meshes.
methodsThree different lightweight polypropylene meshes (TiMESH™ light, ULTRAPRO™, Optilene(®) LP) were tested. All meshes were fixed using 2 ml of each of the three different fibrin glues (TISSUCOL(®), QUIXIL(®), EVICEL(®)) and tested for their biomechanical stability. The defect in the muscle tissue used was 45 mm for a mesh size of 10 × 15 cm. Measurements were conducted using a standardized stamp penetration test, while aiming not to use a fixation strength of less than 32 N.
resultsWith TISSUCOL, the fixation of Optilene LP proved to be significantly better than that of TiMESH or ULTRAPRO (97.3 vs. 47.9 vs. 34.9 N, p < 0.001). With EVICEL, it was possible to also achieve good tissue fixation for the ULTRAPRO mesh, while the results obtained for Optilene and TiMESH were relatively poorer [114.7 vs. 92.4 N (p = 0.056), vs. 64.3 N (p < 0.001)]. With QUIXIL, satisfactory results were obtained only for Optilene LP (43.6 N).
conclusionThis study showed that there were significant differences in the fixation strength of different polypropylene meshes in combination with various fibrin glues. Experiments demonstrated that for each mesh there is an optimum combination with a particular fibrin glue with respect to the fixation strength. It must now be verified whether these results can be extrapolated to clinical practice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.