ArticleJournal of molecular histology2012
Binding of amelogenin to MMP-9 and their co-expression in developing mouse teeth.
Article in Journal of molecular histology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- MMP-9 expression in rat pup incisor teeth is not altered by maternal hypertension or maternal atenolol treatment during pregnancy and lactation.Journal of molecular histology · 2024Article
- Organoids from mouse molar and incisor as new tools to study tooth-specific biology and development.Stem cell reports · 2023Article
- Matrix metalloproteinases gene variants and dental caries in Czech children.BMC oral health · 2020Article
- Gelatinases Cleave Dentin Sialoprotein Intracellularly.Frontiers in physiology · 2020Article
- Amelogenic transcriptome profiling in ameloblast-like cells derived from adult gingival epithelial cells.Scientific reports · 2019Article
- A Potential Role for MMPs during the Formation of Non-Neurogenic Placodes.Journal of developmental biology · 2018Review
- Expression and localization of special AT-rich sequence binding protein 2 in murine molar development and the pulp-dentin complex of human healthy teeth and teeth with pulpitis.Experimental and therapeutic medicine · 2017Article
- Variants on chromosome 4q21 near PKD2 and SIBLINGs are associated with dental caries.Journal of human genetics · 2017Article
- Dentin Sialoprotein is a Novel Substrate of Matrix Metalloproteinase 9 in vitro and in vivo.Scientific reports · 2017Article
- Bmp2 deletion causes an amelogenesis imperfecta phenotype via regulating enamel gene expression.Journal of cellular physiology · 2015Article
- Expression patterns of WNT/β-CATENIN signaling molecules during human tooth development.Journal of molecular histology · 2014Article
- Immunohistochemical localization of Pax6 in the developing tooth germ of mice.Journal of molecular histology · 2014Article
- Kallikrein-related peptidase-4 (KLK4): role in enamel formation and revelations from ablated mice.Frontiers in physiology · 2014Review
- Localization of Beclin1 in mouse developing tooth germs: possible implication of the interrelation between autophagy and apoptosis.Journal of molecular histology · 2013Article
- MMP20 and KLK4 activation and inactivation interactions in vitro.Archives of oral biology · 2013Article
- Dental enamel development: proteinases and their enamel matrix substrates.ISRN dentistry · 2013Review
- Expression and localization of Nell-1 during murine molar development.Journal of molecular histology · 2013Article
- Apoptosis of the reduced enamel epithelium and its implications for bone resorption during tooth eruption.Journal of molecular histology · 2013Article
- Domain of dentine sialoprotein mediates proliferation and differentiation of human periodontal ligament stem cells.PloS one · 2013Article
- Gene Expression Profiling during Murine Tooth Development.Frontiers in genetics · 2012Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
Amelogenin is the most abundant matrix protein in enamel. Proper amelogenin processing by proteinases is necessary for its biological functions during amelogenesis. Matrix metalloproteinase 9 (MMP-9) is responsible for the turnover of matrix components. The relationship between MMP-9 and amelogenin during tooth development remains unknown. We tested the hypothesis that MMP-9 binds to amelogenin and they are co-expressed in ameloblasts during amelogenesis. We evaluated the distribution of both proteins in the mouse teeth using immunohistochemistry and confocal microscopy. At postnatal day 2, the spatial distribution of amelogenin and MMP-9 was co-localized in preameloblasts, secretory ameloblasts, enamel matrix and odontoblasts. At the late stages of mouse tooth development, expression patterns of amelogenin and MMP-9 were similar to that seen in postnatal day 2. Their co-expression was further confirmed by RT-PCR, Western blot and enzymatic zymography analyses in enamel organ epithelial and odontoblast-like cells. Immunoprecipitation assay revealed that MMP-9 binds to amelogenin. The MMP-9 cleavage sites in amelogenin proteins across species were found using bio-informative software program. Analyses of these data suggest that MMP-9 may be involved in controlling amelogenin processing and enamel formation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.