ArticleNeurochemical research2012
Ameliorating effect of fish oil on acrylamide induced oxidative stress and neuronal apoptosis in cerebral cortex.
Article in Neurochemical research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 86 citations in OpenAlex.
- Lycopene ameliorates acrylamide-induced reproductive toxicity through enhancement in testicular antioxidant status and upregulation of androgen receptor expression in male Wistar rats.BMC pharmacology & toxicology · 2026Article
- Ameliorative effects of osthole on acrylamide-induced neurotoxicity in PC12 cells: Role of oxidative stress, apoptosis and ERK pathways.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- The In Vitro, Ex Vivo, and In Vivo Effect of Edible Oils: A Review on Cell Interactions.Pharmaceutics · 2023Review
- Amifostine inhibits acrylamide-induced hepatotoxicity by inhibiting oxidative stress and apoptosis.Iranian journal of basic medical sciences · 2023Article
- The Mechanism of Acrylamide-Induced Neurotoxicity: Current Status and Future Perspectives.Frontiers in nutrition · 2022Review
- Morin protects against acrylamide-induced neurotoxicity in rats: an investigation into different signal pathways.Environmental science and pollution research international · 2021Article
- Metabolomic Profiling and Neuroprotective Effects of Purslane Seeds Extract Against Acrylamide Toxicity in Rat's Brain.Neurochemical research · 2021Article
- Impact of Acrylamide on Cellular Senescence Response and Cell Cycle Distribution via an In-vitro Study.Iranian journal of pharmaceutical research : IJPR · 2021Article
- Role of Oxidative Stress, MAPKinase and Apoptosis Pathways in the Protective Effects of Thymoquinone Against Acrylamide-Induced Central Nervous System Toxicity in Rat.Neurochemical research · 2020Article
- Neuroprotective Effects of Thymoquinone in Acrylamide-Induced Peripheral Nervous System Toxicity Through MAPKinase and Apoptosis Pathways in Rat.Neurochemical research · 2019Article
- Crocin reduced acrylamide-induced neurotoxicity in Wistar rat through inhibition of oxidative stress.Iranian journal of basic medical sciences · 2015Article
- Neuroprotective effect of thymoquinone in acrylamide-induced neurotoxicity in Wistar rats.Iranian journal of basic medical sciences · 2014Article
- Acrylamide exposure impairs blood-cerebrospinal fluid barrier function.Neural regeneration research · 2014Article
- Chrysin reduced acrylamide-induced neurotoxicity in both in vitro and in vivo assessments.Iranian biomedical journal · 2014Article
- Neuroprotective efficacy of eugenol and isoeugenol in acrylamide-induced neuropathy in rats: behavioral and biochemical evidence.Neurochemical research · 2013Article
- Histological and Ultrastructure Study of the Testes of Acrylamide Exposed Adult Male Albino Rat and Evaluation of the Possible Protective Effect of Vitamin E Intake.Journal of microscopy and ultrastructureArticle
- The impact of vitamin E against acrylamide induced toxicity on skeletal muscles of adult male albino rat tongue: Light and electron microscopic study.Journal of microscopy and ultrastructureArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acrylamide (ACR) is a known industrial toxic chemical that produce neurotoxicity characterized by progressive neuronal degeneration. This study was designed to investigate the protective effect of fish oil on ACR-induced neuronal damage in Wistar rats. ACR enhances the production of reactive oxygen species and potentially affects brain. ACR administered rats showed increased levels of lipid peroxidative product, protein carbonyl content, hydroxyl radical and hydroperoxide which were significantly modulated by the supplementation of fish oil. The activities of enzymic antioxidants and levels of reduced glutathione were markedly lowered in ACR-induced rats; fish oil treatment augmented these antioxidant levels in cortex. Free radicals generated during ACR administration reduced the activities of membrane adenosine triphosphatases and acetylcholine esterase. Fish oil enhanced the activities of these enzymes near normal level. Histological observation represented the protective role of fish oil in ACR-induced neuronal damage. Fish oil reduced the ACR-induced apoptosis through the modulation in expressions of B-cell lymphoma 2 (Bcl2)-associated X protein and Bcl2-associated death promoter. Further, fish oil increases the expression of heat shock protein 27 (Hsp27) in ACR-induced rats. This study provides evidence for the neuroprotective effect of fish oil on ACR-induced neurotoxicity by reducing oxidative stress and apoptosis with modulation in the expression of Hsp27.
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