Evidence map›Paper›PMID 22647779›Full record

ArticleNature reviews. Rheumatology2012

Rheumatoid arthritis. Evidence for a genetic component to disease severity in RA.

Eli A Stahl, Soumya Raychaudhuri

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature reviews. Rheumatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Eli A StahlDivisions of Rheumatology and Genetics, Department of Medicine, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
Soumya Raychaudhuri

Funding

Genetic predictors of response to anti-TNF therapy in rheumatoid arthritisU01GM092691 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI BRENNER, MICHAEL B., RAYCHAUDHURI, SOUMYA · 2010 to 2014
$7.5M
Bioinformatics and Population Genetics to Identify Rheumatoid Arthritis GenesK08AR055688 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI RAYCHAUDHURI, SOUMYA · 2008 to 2012
$724k
NIAMS NIH HHS K08 AR055688NIAMS NIH HHS K08AR055688NIGMS NIH HHS U01 GM092691NIGMS NIH HHS U01GM092691
6 · The paper itself

Abstract

Rheumatoid arthritis (RA) is partly heritable; genetic and serological markers are known to confer risk of developing pathology. But given clinical heterogeneity in RA, can we predict who will develop severe disease? Substantial heritability of erosive progression rates has now been identified, but better prognostic biomarkers remain wanting.

Indexed as

Genetic Predisposition to DiseaseQuantitative Trait, HeritableSeverity of Illness IndexArthritis, RheumatoidDisease ProgressionFamily HealthHumansPrognosisRisk Factors

Identifiers

PMID22647779
PMCPMC3668790

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.