Evidence map›Paper›PMID 22647373›Full record

ReviewThe Journal of general virology2012

Application of next-generation sequencing technologies in virology.

Alan D Radford, David Chapman, Linda Dixon, Julian Chantrey, Alistair C Darby, Neil Hall

Open access · greenAbstract readEvaluation StudyReview
In one paragraph

Review in The Journal of general virology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 130 papers.

0numbers the graph read from it
0cells of the map it votes in
130citing papers in PubMed
42.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

130 citing papers in PubMed, 289 citations in OpenAlex.

  1. Article
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  8. Review
  9. Article
  10. First report of fesavirus 4 detection from cats in Japan.The Journal of veterinary medical science · 2024
    Article
  11. Article
  12. Article
  13. Mixed infections with new emerging viruses associated with jujube mosaic disease.International microbiology : the official journal of the Spanish Society for Microbiology · 2023
    Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

70 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Alan D RadfordUniversity of Liverpool, Institute of Infection and Global Health, Leahurst Campus, Chester High Road, Neston, South Wirral CH64 7TE, UK.
David ChapmanInstitute for Animal Health, Pirbright Laboratory, Ash Road, Pirbright, Woking, Surrey GU24 0NF, UK.
Linda DixonInstitute for Animal Health, Pirbright Laboratory, Ash Road, Pirbright, Woking, Surrey GU24 0NF, UK.
Julian ChantreyUniversity of Liverpool, School of Veterinary Science, Leahurst Campus, Chester High Road, Neston, South Wirral CH64 7TE, UK.
Alistair C DarbyInstitute of Integrative Biology, Biosciences Building, Crown Street, University of Liverpool, Liverpool L69 7ZB, UK.
Neil HallInstitute of Integrative Biology, Biosciences Building, Crown Street, University of Liverpool, Liverpool L69 7ZB, UK.
University of Liverpool · GBThe Pirbright Institute · GB

Funding

Biotechnology and Biological Sciences Research Council BB/H008969/1Biotechnology and Biological Sciences Research Council BBS/E/I/00001003
6 · The paper itself

Abstract

The progress of science is punctuated by the advent of revolutionary technologies that provide new ways and scales to formulate scientific questions and advance knowledge. Following on from electron microscopy, cell culture and PCR, next-generation sequencing is one of these methodologies that is now changing the way that we understand viruses, particularly in the areas of genome sequencing, evolution, ecology, discovery and transcriptomics. Possibilities for these methodologies are only limited by our scientific imagination and, to some extent, by their cost, which has restricted their use to relatively small numbers of samples. Challenges remain, including the storage and analysis of the large amounts of data generated. As the chemistries employed mature, costs will decrease. In addition, improved methods for analysis will become available, opening yet further applications in virology including routine diagnostic work on individuals, and new understanding of the interaction between viral and host transcriptomes. An exciting era of viral exploration has begun, and will set us new challenges to understand the role of newly discovered viral diversity in both disease and health.

Indexed as

AnimalsHigh-Throughput Nucleotide SequencingHumansSequence Analysis, DNAVirologyViruses

Identifiers

PMID22647373
PMCPMC3709572
OpenAlexW2141558216

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.