Evidence map›Paper›PMID 22647357›Full record

ReviewCancer journal (Sudbury, Mass.)

Causes and consequences of microRNA dysregulation.

Marilena V Iorio, Carlo M Croce

Erratum issuedAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancer journal (Sudbury, Mass.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 172 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
172citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

172 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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112 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Marilena V IorioStart Up Unit, Department of Experimental Oncology, Fondazione IRCCS, Istituto Nazionale Tumori, Milano, Italy.
Carlo M Croce

Funding

The Role of Epigenetic Factors in Regulation of Coding and Non-Coding HOX GenesP01CA129242 · NCI · OHIO STATE UNIVERSITY · PI CROCE, CARLO M · 2009 to 2013
$4.7M
MiRNAs/UCRs: biomarkers for cancer risk, tumor detection, progression & treatmentU01CA152758 · NCI · OHIO STATE UNIVERSITY · PI CROCE, CARLO M · 2010 to 2014
$1.8M
TOWARD AN UNDERSTANDING OF CLL PROGRESSIONR01CA151319 · NCI · OHIO STATE UNIVERSITY · PI CROCE, CARLO M · 2011 to 2015
$1.5M
NCI NIH HHS P01 CA129242NCI NIH HHS R01 CA151319NCI NIH HHS U01 CA152758
6 · The paper itself

Abstract

It is currently well recognized that microRNA deregulation is a hallmark of human cancer, and an aberrant expression of these tiny regulatory RNA molecules in several cell types is not just a random association, but it also plays a causal role in different steps of the tumorigenic process, from the initiation and development to progression toward the acquisition of a metastatic phenotype. Different regulatory mechanisms can control microRNA expression at a genetic or epigenetic level as well as involve the biogenesis machinery or the recruitment of specific transcription factors. The tumorigenic process implies a substantial alteration of these mechanisms, thus disrupting the equilibrium within the cell and leading to a global change in microRNA expression, with loss of oncosuppressor microRNAs and overexpression of oncomiRNAs. We review the main mechanisms regulating microRNAs and the consequences of their aberrant expression in cancer, with a glance at the possible implications at a clinical point of view.

Indexed as

Cell Transformation, NeoplasticGene Expression Regulation, NeoplasticHumansMicroRNAsNeoplasm MetastasisNeoplasmsMicroRNAs

Identifiers

PMID22647357
PMCPMC3528102

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.