ArticleAnnals of intensive care2012
Urea for treatment of acute SIADH in patients with subarachnoid hemorrhage: a single-center experience.
Article in Annals of intensive care, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Use of Urea for the Syndrome of Inappropriate Secretion of Antidiuretic Hormone: A Systematic Review.JAMA network open · 2023Pooled it
- Development of Carboxymethyl Cellulose-Gelatin Aerogels for Urea Delivery.AAPS PharmSciTech · 2026Article
- Syndrome of Inappropriate Antidiuresis.Journal of the American Society of Nephrology : JASN · 2025Review
- Clinical factors associated with hyponatremia correction during treatment with oral urea.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025Article
- Syndrome of Inappropriate Antidiuresis: From Pathophysiology to Management.Endocrine reviews · 2023Review
- Disorders of Salt and Water Balance After Pituitary Surgery.The Journal of clinical endocrinology and metabolism · 2022Article
- Clinical efficacy of urea treatment in syndrome of inappropriate antidiuretic hormone secretion.Scientific reports · 2022Article
- Syndrome of inappropriate antidiuretic hormone associated with eosinophilic granulomatosis and polyangiitis.BMJ case reports · 2020Article
- Review
- Investigation and management of moderate to severe inpatient hyponatraemia in an Australian tertiary hospital.BMC endocrine disorders · 2018Article
- Systemic Complications Following Aneurysmal Subarachnoid Hemorrhage.Current neurology and neuroscience reports · 2017Review
- SIAD: practical recommendations for diagnosis and management.Journal of endocrinological investigation · 2016Review
- Hyponatremia in the intensive care unit: How to avoid a Zugzwang situation?Annals of intensive care · 2015Article
- Tuberculous lymphadenitis and syndrome of inappropriate antidiuresis, improbable partners.BMJ case reports · 2015Article
- Diagnosis and Management of Hyponatremia in Patients with Aneurysmal Subarachnoid Hemorrhage.Journal of clinical medicine · 2015Article
- [Hyponatremia: differential diagnosis and therapy].Der Internist · 2014Article
- Neurosurgical Hyponatremia.Journal of clinical medicine · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHyponatremia occurring as a result of the syndrome of inappropriate antidiuretic hormone secretion (SIADH) or cerebral salt wasting syndrome is a common complication in patients with subarachnoid hemorrhage (SAH). The efficacy and safety of urea as treatment for SIADH-induced hyponatremia has not been reported in this population.
methodsThis is a retrospective analysis of all patients admitted to our department for nontraumatic SAH between January 2003 and December 2008 (n = 368). All patients with SIADH-induced hyponatremia (plasma sodium < 135 mEq/L, urine sodium > 20 mEq/L, and osmolality > 200 mOsm/kg; absence of overt dehydration or hypovolemia; no peripheral edema or renal failure; no history of adrenal or thyroid disease) routinely received urea per os when hyponatremia was associated with clinical deterioration or remained less than 130 mEq/L despite saline solution administration.
resultsForty-two patients developed SIADH and were treated with urea. Urea was started after a median of 7 (IQR, 5-10) days and given orally at doses of 15-30 g tid or qid for a median of 5 (IQR, 3-7) days. The median plasma sodium increase over the first day of treatment was 3 (IQR, 1-6) mEq/L. Hyponatremia was corrected in all patients, with median times to Na+ >130 and >135 mEq/L of 1 (IQR, 1-2) and 3 (IQR, 2-4) days, respectively. Urea was well tolerated, and no adverse effects were reported.
conclusionsOral urea is an effective and well-tolerated treatment for SIADH-induced hyponatremia in SAH patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.